Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex
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Autophagy in malignant transformation and cancer progressionNegative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.The role of oxidative stress and autophagy in atherosclerosisA Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.Dynamins and BAR Proteins-Safeguards against Cancer.The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stressBeclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiologyBcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG.BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5.Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutasemiR-183 regulates autophagy and apoptosis in colorectal cancer through targeting of UVRAGULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models.Emerging nexus between RAB GTPases, autophagy and neurodegeneration.Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells.An autophagy-independent function for Beclin 1 in cancer.BECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradationDistinct Rab7-related Endosomal-Autophagic-Lysosomal Dysregulation Observed in Cortex and Hippocampus in APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease.NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models.Autophagy Biomarkers Beclin 1 and p62 are Increased in Cerebrospinal Fluid after Traumatic Brain Injury.Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking.Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in miceThe Mitochondrion-lysosome Axis in Adaptive and Innate Immunity: Effect of Lupus Regulator Peptide P140 on Mitochondria Autophagy and NETosis
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P2860
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@ast
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@en
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@nl
type
label
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@ast
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@en
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@nl
prefLabel
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@ast
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@en
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@nl
P2093
P2860
P1433
P1476
Beclin 1 is required for neuro ...... ys via the UVRAG-VPS34 complex
@en
P2093
Greg R Phillips
Mitchell S Wold
Nathaniel Heintz
Nicole C McKnight
Shiaoching Gong
Wei-Xing Zong
Zhenyu Yue
Zhixun Dou
P2860
P304
P356
10.1371/JOURNAL.PGEN.1004626
P407
P577
2014-10-02T00:00:00Z