Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest
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Visualizing Vpr-induced G2 arrest and apoptosisFluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus.Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest.Vpr-host interactions during HIV-1 viral life cycle.HIV-1 Vpr and G2 cell cycle arrest.HIV-1 Vpr redirects host ubiquitination pathway.Modulation of NKG2D-mediated cytotoxic functions of natural killer cells by viral protein R from HIV-1 primary isolates.HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair responseExtracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir.HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteinsActivation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 RecruitmentThe phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions.The HIV-derived protein Vpr52-96 has anti-glioma activity in vitro and in vivo.Viral protein R upregulates expression of ULBP2 on uninfected bystander cells during HIV-1 infection of primary CD4+ T lymphocytesDelineating HIV-associated neurocognitive disorders using transgenic models: the neuropathogenic actions of Vpr.HIV-1, ubiquitin and ubiquitin-like proteins: the dialectic interactions of a virus with a sophisticated network of post-translational modifications.Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase.Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr.Characterization of the interaction between human respiratory syncytial virus and the cell cycle in continuous cell culture and primary human airway epithelial cells.SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells.Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells.Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1.Cep78 controls centrosome homeostasis by inhibiting EDD-DYRK2-DDB1VprBP.Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription.HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infectionMolecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase.Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability.HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.HIV-1 Vpr Reprograms CLR4 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection
P2860
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P2860
Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest
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2010 nî lūn-bûn
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2010 թուականին հրատարակուած գիտական յօդուած
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2010 թվականին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@ast
Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@en
Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@nl
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Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@ast
Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@en
Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@nl
prefLabel
Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@ast
Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@en
Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@nl
P2093
P2860
P3181
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P1476
Formation of mobile chromatin- ...... uction of G2 cell cycle arrest
@en
P2093
Eric A Cohen
Francine C A Gérard
Jean-Philippe Belzile
Levon G Abrahamyan
Nicole Rougeau
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1001080
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P577
2010-01-01T00:00:00Z