Atomic structure of the APC/C and its mechanism of protein ubiquitination.
about
Insights into APC/C: from cellular function to diseases and therapeuticsDual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1Structure of transcribing mammalian RNA polymerase IICryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationAPC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathwayA decade of the anaphase-promoting complex in the nervous systemCrystal Structure of a Ube2S-Ubiquitin ConjugateMolecular mechanism of APC/C activation by mitotic phosphorylation.Molecular basis of APC/C regulation by the spindle assembly checkpoint.The industrial melanism mutation in British peppered moths is a transposable element.An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S TransitionAtomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.Mechanism of APC/CCDC20 activation by mitotic phosphorylation.TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth.Protein domain mapping by internal labeling and single particle electron microscopy.O-GlcNAcylation Antagonizes Phosphorylation of CDH1 (CDC20 Homologue 1)PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27.Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated ProteolysisCapturing a substrate in an activated RING E3/E2-SUMO complex.WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.Unravelling biological macromolecules with cryo-electron microscopy.APC/CCDC20 and APC/C play pivotal roles in the process of embryonic development in Artemia sinica.UBE2C is overexpressed in ESCC tissues and its abrogation attenuates the malignant phenotype of ESCC cell lines.mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27.Measuring APC/C-Dependent Ubiquitylation In Vitro.The hunt for antimitotic agents: an overview of structure-based design strategies.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.Cryo-EM of bacterial pili and archaeal flagellar filaments.Cdc20 directs proteasome-mediated degradation of the tumor suppressor SMAR1 in higher grades of cancer through the anaphase promoting complex.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.The APC/C Coordinates Retinal Differentiation with G1 Arrest through the Nek2-Dependent Modulation of Wingless Signaling.Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C.Forkhead Box M1 positively regulates UBE2C and protects glioma cells from autophagic death.APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates.
P2860
Q26740196-601D3DBB-A4B2-4A68-9236-3D9D663CBA7BQ27304870-9BDF5880-C64B-4CB2-9E19-0ACEB5B66C7EQ27703642-2DFBB227-4E8D-4001-9276-C9246D736107Q27727603-88D06714-D962-43F3-820B-8AFA35A885D2Q28072560-15A71B52-FCEC-4781-B16C-57C16EDD5935Q28073361-F950DA2A-C766-42EE-BD20-3CDF4960784DQ28553007-F6E4539F-836E-45EA-8FEE-2A54CD7BFB54Q30761154-AD7C2C4D-E902-456F-9644-2145536A4316Q30810456-A20E3DA2-37DD-4BCD-9A11-D73F367CA2FDQ34529231-51EE39DD-DAF2-4559-97A2-92BBA4F42D5AQ36075210-838980C2-2486-4EE0-B352-3868E1850567Q36111232-D265A850-8F3A-4792-B759-77D3B5A90665Q36115907-14B6EBF8-A248-4B6F-8F40-BBEC5CCF64FBQ36360931-C66420B0-C327-45C2-A0E4-5ACBA9CE9C16Q36905102-2C4FC1D4-7BC8-4701-9116-0CF555EA73E2Q36956981-2F60950B-7F24-41DB-91E8-A2EB4EBA326FQ37038083-2E7BE501-B1C5-4E37-99FC-7FB37C425F23Q37065998-461CB9E3-7E06-447B-B7E4-4CA0A1C550B3Q37114286-1070AD08-6542-4DA2-B3A3-99528D487160Q37117276-D17D92FA-7DD2-4F48-A85D-25D123740258Q37249161-4EA75454-BDFD-4BEB-B326-2B8B102AB9D4Q37281514-1378B22D-5475-470D-B73B-26BF8E0A877FQ37357527-42D2DC3B-CCE9-4ACB-8713-766F3AA82E4BQ37519223-1949B195-F8A7-4DDC-84C3-C789182DC010Q37662326-04DDD17B-2943-4804-9762-FB823816CBE6Q37701597-09E6FE63-47CD-48DF-B721-2DC4CB46CF11Q38562963-B45C82E2-B9E5-47CF-8521-3FBAC5739099Q38808120-4FC7B7C7-372A-4602-B3B2-1C1707E9D028Q38916854-74052922-39E6-4A51-87CC-A8237083A22AQ38975034-F8A110EF-8144-4299-A153-AC18B5133BEDQ39149390-BBA68FBF-1E8C-4111-AEA5-501D8E49DF4DQ39369852-A480601E-2DDD-4FC2-8440-35D6B6D5F060Q41084291-35114ED2-67D3-408C-8FF1-BB205E367A2DQ41146841-08BC42E7-A9E3-489C-91C9-4CFD44F4CADAQ41193829-05EB660E-70E2-4433-871A-75495F33D3F7Q41546924-B6BBE890-D863-4164-8697-8B50256FC02AQ41627572-9C545DE0-5EFD-4C5B-AD6F-EB87CDE10F87Q41698570-73CF410A-417D-49CB-9C94-C7F7AE9E5BC3Q42322723-0E98089E-618B-4396-AA7B-657A209D078CQ44551840-DEE2D667-03F4-4C10-BE90-C7FFD21FEAE5
P2860
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
name
Atomic structure of the APC/C and its mechanism of protein ubiquitination
@nl
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
@ast
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
@en
type
label
Atomic structure of the APC/C and its mechanism of protein ubiquitination
@nl
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
@ast
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
@en
prefLabel
Atomic structure of the APC/C and its mechanism of protein ubiquitination
@nl
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
@ast
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
@en
P2860
P50
P921
P3181
P356
P1433
P1476
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
@en
P2093
David Barford
Leifu Chang
P2860
P2888
P304
P3181
P356
10.1038/NATURE14471
P407
P577
2015-06-15T00:00:00Z
P5875
P6179
1048330683