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The cellular and molecular basis of bitter tastant-induced bronchodilation

The cellular and molecular basis of bitter tastant-induced bronchodilation

http://www.wikidata.org/entity/Q27318226

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Inhibition of G-protein βγ signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cells Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.Non-selective cation channels mediate chloroquine-induced relaxation in precontracted mouse airway smooth muscle The expression and relaxant effect of bitter taste receptors in human bronchi.Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation Evaluation of Mucociliary Clearance by Three Dimension Micro-CT-SPECT in Guinea Pig: Role of Bitter Taste Agonists.Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction.Involvement of large-conductance Ca2+-activated K+ channels in chloroquine-induced force alterations in pre-contracted airway smooth muscle.Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells.The Pharmacochaperone Activity of Quinine on Bitter Taste Receptors.Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.Inhibition of Gαs/cAMP Signaling Decreases TCR-Stimulated IL-2 transcription in CD4(+) T Helper Cells.Inhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4(+) T Helper Cells.How sweet it is: intestinal sweet taste receptors in type 2 diabetes Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms Airway smooth muscle in airway reactivity and remodeling: what have we learned?Chloride channel blockers promote relaxation of TEA-induced contraction in airway smooth muscle.KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways.Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.Chemical reporters for biological discovery.Bitter taste genetics--the relationship to tasting, liking, consumption and health.The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity.Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease.Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones.Rosiglitazone is a superior bronchodilator compared to chloroquine and β-adrenoceptor agonists in mouse lung slices.Denatonium inhibits growth and induces apoptosis of airway epithelial cells through mitochondrial signaling pathways Extraoral bitter taste receptors in health and disease.Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.Bitter taste receptors as targets for tocolytics in preterm labor therapy.Impaired Relaxation of Airway Smooth Muscle in Mice Lacking the Actin-Binding Protein Gelsolin.Activation of bitter taste receptors in pulmonary nociceptors sensitizes TRPV1 channels through the PLC and PKC signaling pathway.Bitter tastants induce relaxation of rat thoracic aorta precontracted with high K(+).Members of Bitter Taste Receptor Cluster Tas2r143/Tas2r135/Tas2r126 Are Expressed in the Epithelium of Murine Airways and Other Non-gustatory Tissues.Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice.Chloride channels blockers promote relaxation of TEA-induced contraction in airway smooth muscle.Reception of Aversive Taste.Distinct Effects of Ca2+ Sparks on Cerebral Artery and Airway Smooth Muscle Cell Tone in Mice and Humans.Analysis of the expression of human bitter taste receptors in extraoral tissues.The relative contributions of store-operated and voltage-gated Ca2+ channels to the control of Ca2+ oscillations in airway smooth muscle.

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The cellular and molecular basis of bitter tastant-induced bronchodilation

http://www.wikidata.org/entity/Q27318226

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2013 nî lūn-bûn

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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type

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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The cellular and molecular basis of bitter tastant-induced bronchodilation

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Cheng-Hai Zhang

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Karl F Uy

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Kevin E Fogarty

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Lawrence M Lifshitz

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Mitsuo Ikebe

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Ronghua ZhuGe

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P2860

Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium

T2Rs function as bitter taste receptors

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

Role of depolarization in acetylcholine-induced contractions of dog trachealis muscle

Motile cilia of human airway epithelia are chemosensory

Functional expression of the taste specific G-protein, alpha-gustducin

Cholinergic chemosensory cells in the trachea regulate breathing

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways

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