Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock - Wikidata - wikimedia - TriplyDB

Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock

Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock

http://www.wikidata.org/entity/Q27321007

about

Gram-positive and gram-negative bacterial toxins in sepsis: a brief review PI3K/Akt/mTOR, a pathway less recognized for staphylococcal superantigen-induced toxicity The staphylococcal enterotoxin (SE) family: SEB and siblings Staphylococcal superantigens in colonization and disease Emerging therapeutic targets of sepsis-associated acute kidney injury.Uptake and intracellular trafficking of superantigens in dendritic cells.Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology.Staphylococcal superantigens interact with multiple host receptors to cause serious diseases.Clarifying the mechanism of superantigen toxicity Activated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.Staphylococcal and streptococcal superantigen exotoxins The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis.Disease manifestations and pathogenic mechanisms of Group A Streptococcus.The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.Single administration of p2TA (AB103), a CD28 antagonist peptide, prevents inflammatory and thrombotic reactions and protects against gastrointestinal injury in total-body irradiated mice CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis.Heat shock transcription factor 1 is activated as a consequence of lymphocyte activation and regulates a major proteostasis network in T cells critical for cell division during stress Innate Immune Signaling Activated by MDR Bacteria in the Airway Antagonist properties of monoclonal antibodies targeting human CD28: role of valency and the heavy-chain constant domain In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.Staphylococcal Enterotoxin O Exhibits Cell Cycle Modulating Activity.A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes.Role of pore-forming toxins in neonatal sepsis Probiotic Lactobacilli Modulate Staphylococcus aureus-Induced Activation of Conventional and Unconventional T cells and NK Cells.IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection Staphylococcal entertotoxins of the enterotoxin gene cluster (egcSEs) induce nitrous oxide- and cytokine dependent tumor cell apoptosis in a broad panel of human tumor cells.CD28: direct and critical receptor for superantigen toxins Update on staphylococcal superantigen-induced signaling pathways and therapeutic interventions.Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction.The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?Bacterial superantigen toxins induce a lethal cytokine storm by enhancing B7-2/CD28 costimulatory receptor engagement, a critical immune checkpoint.Streptococcal toxins: role in pathogenesis and disease.Animal Models Used to Study Superantigen-Mediated Diseases.B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection.Stress-caused anergy of leukocytes towards Staphylococcal enterotoxin B and exposure transcriptome signatures.Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans.Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm.Superantigens induce IL-17 production from polarized Th1 clones.The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response.Correction: Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock.

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Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock

http://www.wikidata.org/entity/Q27321007

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2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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Binding of superantigen toxins ...... enes that mediate lethal shock

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Binding of superantigen toxins ...... enes that mediate lethal shock

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Binding of superantigen toxins ...... enes that mediate lethal shock

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Binding of superantigen toxins ...... enes that mediate lethal shock

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Binding of superantigen toxins ...... enes that mediate lethal shock

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Dalia Hillman

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P2860

A novel transcription factor, T-bet, directs Th1 lineage commitment

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

Crystal structure of the superantigen staphylococcal enterotoxin type A

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

Crystal structure of a T-cell receptor beta-chain complexed with a superantigen

Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors

Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity

Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR

The B7 family revisited

Crystal structure of a soluble CD28-Fab complex

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