Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock
about
Gram-positive and gram-negative bacterial toxins in sepsis: a brief reviewPI3K/Akt/mTOR, a pathway less recognized for staphylococcal superantigen-induced toxicityThe staphylococcal enterotoxin (SE) family: SEB and siblingsStaphylococcal superantigens in colonization and diseaseEmerging therapeutic targets of sepsis-associated acute kidney injury.Uptake and intracellular trafficking of superantigens in dendritic cells.Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology.Staphylococcal superantigens interact with multiple host receptors to cause serious diseases.Clarifying the mechanism of superantigen toxicityActivated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.Staphylococcal and streptococcal superantigen exotoxinsThe contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis.Disease manifestations and pathogenic mechanisms of Group A Streptococcus.The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.Single administration of p2TA (AB103), a CD28 antagonist peptide, prevents inflammatory and thrombotic reactions and protects against gastrointestinal injury in total-body irradiated miceCD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis.Heat shock transcription factor 1 is activated as a consequence of lymphocyte activation and regulates a major proteostasis network in T cells critical for cell division during stressInnate Immune Signaling Activated by MDR Bacteria in the AirwayAntagonist properties of monoclonal antibodies targeting human CD28: role of valency and the heavy-chain constant domainIn the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.Staphylococcal Enterotoxin O Exhibits Cell Cycle Modulating Activity.A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes.Role of pore-forming toxins in neonatal sepsisProbiotic Lactobacilli Modulate Staphylococcus aureus-Induced Activation of Conventional and Unconventional T cells and NK Cells.IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infectionStaphylococcal entertotoxins of the enterotoxin gene cluster (egcSEs) induce nitrous oxide- and cytokine dependent tumor cell apoptosis in a broad panel of human tumor cells.CD28: direct and critical receptor for superantigen toxinsUpdate on staphylococcal superantigen-induced signaling pathways and therapeutic interventions.Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction.The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?Bacterial superantigen toxins induce a lethal cytokine storm by enhancing B7-2/CD28 costimulatory receptor engagement, a critical immune checkpoint.Streptococcal toxins: role in pathogenesis and disease.Animal Models Used to Study Superantigen-Mediated Diseases.B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection.Stress-caused anergy of leukocytes towards Staphylococcal enterotoxin B and exposure transcriptome signatures.Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans.Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm.Superantigens induce IL-17 production from polarized Th1 clones.The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response.Correction: Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock.
P2860
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P2860
Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Binding of superantigen toxins ...... enes that mediate lethal shock
@ast
Binding of superantigen toxins ...... enes that mediate lethal shock
@en
Binding of superantigen toxins ...... enes that mediate lethal shock
@nl
type
label
Binding of superantigen toxins ...... enes that mediate lethal shock
@ast
Binding of superantigen toxins ...... enes that mediate lethal shock
@en
Binding of superantigen toxins ...... enes that mediate lethal shock
@nl
prefLabel
Binding of superantigen toxins ...... enes that mediate lethal shock
@ast
Binding of superantigen toxins ...... enes that mediate lethal shock
@en
Binding of superantigen toxins ...... enes that mediate lethal shock
@nl
P2093
P2860
P3181
P1433
P1476
Binding of superantigen toxins ...... enes that mediate lethal shock
@en
P2093
Dalia Hillman
Emmanuelle Supper
Iris Nasie
Raymond Kaempfer
Revital Levy
Uri Barash
Ziv Rotfogel
P2860
P304
P3181
P356
10.1371/JOURNAL.PBIO.1001149
P407
P577
2011-09-01T00:00:00Z