Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation - Wikidata - wikimedia - TriplyDB

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

http://www.wikidata.org/entity/Q27329025

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Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan Sirtuin to the rescue: SIRT2 extends life span of BubR1 mice.How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse models Comparison of mice with accelerated aging caused by distinct mechanisms Aneuploidy in health, disease, and aging.BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer p21 both attenuates and drives senescence and aging in BubR1 progeroid mice How unfinished business from S-phase affects mitosis and beyond Genomic instability and colon carcinogenesis: from the perspective of genes.Aneuploidy: implications for protein homeostasis and disease Emerging links among Chromosome Instability (CIN), cancer, and aging.Mitotic Dysfunction Associated with Aging Hallmarks.Prevalence of germline mutations in the spindle assembly checkpoint gene BUB1B in individuals with early-onset colorectal cancer.Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human.The Role of Centromere Defects in Cancer.FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence Analysis of the role of GSK3 in the mitotic checkpoint

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P2860

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

http://www.wikidata.org/entity/Q27329025

description

2012 nî lūn-bûn

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2012 թուականին հրատարակուած գիտական յօդուած

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2012 թվականին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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type

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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JOURNAL.PGEN.1003138

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

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Bart van de Sluis

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Darren J Baker

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Jan M van Deursen

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Karthik B Jeganathan

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Liviu A Malureanu

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P2860

Mutations of mitotic checkpoint genes in human cancers

A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons

CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity

Chromosomal instability and cancer: a complex relationship with therapeutic potential

Human aneuploidy: mechanisms and new insights into an age-old problem

The spindle-assembly checkpoint in space and time

Aging and genome maintenance: lessons from the mouse?

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Reprogramming to pluripotency can conceal somatic cell chromosomal instability

A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation

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e1003138

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scholarly article

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10.1371/JOURNAL.PGEN.1003138

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12

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8

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Tobias Wijshake

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2012-12-27T00:00:00Z

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234090059

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