Vinculin controls talin engagement with the actomyosin machinery.
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Adhesion protein networks reveal functions proximal and distal to cell-matrix contactsMechanosensitive components of integrin adhesions: Role of vinculinTalin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.Cooperative Vinculin Binding to Talin Mapped by Time-Resolved Super Resolution Microscopy.Mechanical stability of talin rod controls cell migration and substrate sensing.Vinculin in cell-cell and cell-matrix adhesions.LD Motif Recognition by Talin: Structure of the Talin-DLC1 ComplexThe mechanical response of talin.Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes.Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites.The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix.The nucleus is a conserved mechanosensation and mechanoresponse organelle.αvβ3 integrins negatively regulate cellular forces by phosphorylation of its distal NPXY site.Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity.Cell adhesion and invasion mechanisms that guide developing axonsIntegrin-mediated mechanotransduction.Molecular stretching modulates mechanosensing pathways.Talin - the master of integrin adhesions.Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation.Zygotic vinculin is not essential for embryonic development in zebrafish.Effects of substrate stiffness and actomyosin contractility on coupling between force transmission and vinculin-paxillin recruitment at single focal adhesions.Distinct focal adhesion protein modules control different aspects of mechanotransduction.Vinculin is required to maintain glomerular barrier integrity.Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy.Integrin-bound talin head inhibits actin filament barbed end elongation.Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1.Talin gets SHANKed in the fight for integrin activation.Vinculin Force-Sensitive Dynamics at Focal Adhesions Enable Effective Directed Cell Migration.Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex.
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P2860
Vinculin controls talin engagement with the actomyosin machinery.
description
2015 nî lūn-bûn
@nan
2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Vinculin controls talin engagement with the actomyosin machinery
@nl
Vinculin controls talin engagement with the actomyosin machinery.
@ast
Vinculin controls talin engagement with the actomyosin machinery.
@en
type
label
Vinculin controls talin engagement with the actomyosin machinery
@nl
Vinculin controls talin engagement with the actomyosin machinery.
@ast
Vinculin controls talin engagement with the actomyosin machinery.
@en
prefLabel
Vinculin controls talin engagement with the actomyosin machinery
@nl
Vinculin controls talin engagement with the actomyosin machinery.
@ast
Vinculin controls talin engagement with the actomyosin machinery.
@en
P2093
P2860
P50
P3181
P356
P1476
Vinculin controls talin engagement with the actomyosin machinery
@en
P2093
David R Critchley
De-Yao Wang
Devina Jethwa
Eugenia Meiler-Rodriguez
Igor L Barsukov
Pengbo Wang
Ricky Tsang
P2860
P2888
P3181
P356
10.1038/NCOMMS10038
P407
P577
2015-12-04T00:00:00Z
P5875
P6179
1028042418