about
Mechanism of CDK5/p25 binding by CDK inhibitorsStructural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitorsThe small molecule indirubin-3'-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.Indirubin-3'-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice.The Small Molecule Indirubin-3'-Oxime Inhibits Protein Kinase R: Antiapoptotic and Antioxidant Effect in Rat Cardiac Myocytes.Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β.Neuroprotective role of Indirubin-3'-monoxime, a GSKβ inhibitor in high fat diet induced cognitive impairment in mice.Indirubin-3'-oxime induces mitochondrial dysfunction and triggers growth inhibition and cell cycle arrest in human neuroblastoma cells.Antiplatelet action of indirubin-3'-monoxime through suppression of glycoprotein VI-mediated signal transduction: a possible role for ERK signaling in platelets.Indirubin-3'-oxime inhibits inflammatory activation of rat brain microglia.Indirubin-3'-oxime reverses bone loss in ovariectomized and hindlimb-unloaded mice via activation of the Wnt/β-catenin signaling
P921
Q24293582-06437038-B703-4243-BDAB-2EA2315B3D0CQ27642297-CB2D73AD-C5AE-4133-9438-1D54F626427BQ34018084-9FE1CE5C-B210-4CAC-82B3-1BC8BC36F7AEQ38996268-96789060-EAB0-4B4E-AF31-618D79A071F2Q46639237-069776FA-DC34-4A95-AD2F-67B0D047D29FQ46673204-FE36AE47-C245-48A7-A9A4-6BEB487E3C67Q48532082-0782BFDD-8405-4E7C-A2AC-84AE75FAF988Q53136248-C541A522-C9C6-4764-8D70-8EDC8EAFE23BQ54305754-3FFC8097-F3C9-4FB7-AAEB-625F63D10A6DQ54642942-9EB1DB1F-A524-4452-8C3B-AD04EACFBB41Q86766400-CBA237A4-626B-45D1-ABDD-8FFBBFAA51D2
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
(Z)-1H,1'H-[2,3']biindolylidene-3,2'-dione-3-oxime
@en
type
label
(Z)-1H,1'H-[2,3']biindolylidene-3,2'-dione-3-oxime
@en
altLabel
Indirubin-3'-Monoxime
@en
prefLabel
(Z)-1H,1'H-[2,3']biindolylidene-3,2'-dione-3-oxime
@en
P638
P592
P661
P683
P1579
P2017
C1=CC=C2C(=C1)/C(=C/3\C(\C4=CC=CC=C4N3)=N\O)/C(=N2)O
P2067
P233
C1=CC=C2C(=C1)C(=C3C(C4=CC=CC=C4N3)=NO)C(=N2)O
P234
1S/C16H11N3O2/c20-16-13(9-5-1- ...... 7,21H,(H,18,20)/b15-13-,19-14+
P235
HBDSHCUSXQATPO-BGBJRWHRSA-N
P592
CHEMBL216543