Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees.
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The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosisPolo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5ACellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replicationPhosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replicationAnimal models for the study of HCVNew hepatitis C virus drug discovery strategies and model systemsRobust hepatitis C virus infection in vitro.Quantitative Analysis of the Hepatitis C Virus Replication ComplexInteraction between Brome mosaic virus proteins and RNAs: effects on RNA replication, protein expression, and RNA stabilityProduction of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cellsA milestone for hepatitis C virus research: A virus generated in cell culture is fully viable in vivoCell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitroReplication of a hepatitis C virus replicon clone in mouse cellsThe Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A HyperphosphorylationProduction of Infectious Hepatitis C Virus of Various Genotypes in Cell CulturesIn Vivo Study of the HC-TN Strain of Hepatitis C Virus Recovered from a Patient with Fulminant Hepatitis: RNA Transcripts of a Molecular Clone (pHC-TN) Are Infectious in Chimpanzees but Not in Huh7.5 CellsThe NS3 Helicase and NS5B-to-3'X Regions Are Important for Efficient Hepatitis C Virus Strain JFH-1 Replication in Huh7 CellsStudying Hepatitis C Virus: Making the Best of a Bad VirusThe p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequencesCell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted VariantEffects of Mutagenic and Chain-Terminating Nucleotide Analogs on Enzymes Isolated from Hepatitis C Virus Strains of Various GenotypesIntragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell deathHepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutationProduction of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing MutationsHepatitis C virus replicons: dinosaurs still in business?Hepatitis C Virus entry: the early steps in the viral replication cycleA Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus AssemblyArchitects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesisA Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across GenotypesProduction of infectious hepatitis C virus in tissue culture from a cloned viral genomeUnravelling hepatitis C virus replication from genome to functionVinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studiesHepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasome.An in vitro model of hepatitis C virion productionA new model to produce infectious hepatitis C virus without the replication requirement.Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein.Hepatitis C virus experimental model systems and antiviral drug research.Bile acids specifically increase hepatitis C virus RNA-replication.Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.
P2860
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P2860
Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees.
description
2002 nî lūn-bûn
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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Mutations that permit efficien ...... ive replication in chimpanzees
@nl
Mutations that permit efficien ...... ve replication in chimpanzees.
@ast
Mutations that permit efficien ...... ve replication in chimpanzees.
@en
type
label
Mutations that permit efficien ...... ive replication in chimpanzees
@nl
Mutations that permit efficien ...... ve replication in chimpanzees.
@ast
Mutations that permit efficien ...... ve replication in chimpanzees.
@en
prefLabel
Mutations that permit efficien ...... ive replication in chimpanzees
@nl
Mutations that permit efficien ...... ve replication in chimpanzees.
@ast
Mutations that permit efficien ...... ve replication in chimpanzees.
@en
P2093
P2860
P50
P3181
P356
P1476
Mutations that permit efficien ...... ve replication in chimpanzees.
@en
P2093
Kristina Faulk
Marisa St Claire
Max Shapiro
Nicole Krieger
Ronald E Engle
Sugantha Govindarajan
Thomas Pietschmann
P2860
P304
14416-14421
P3181
P356
10.1073/PNAS.212532699
P407
P577
2002-10-21T00:00:00Z