Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
about
An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication.Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymeraseHepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5Acis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genomeStructural characterization of the highly conserved 98-base sequence at the 3' end of HCV RNA genome and the complementary sequence located at the 5' end of the replicative viral strandInhibitors of the Hepatitis C Virus Polymerase; Mode of Action and ResistanceStructures of hepatitis C virus nonstructural proteins required for replicase assembly and functionCommon and unique features of viral RNA-dependent polymerasesSpatiotemporal analysis of hepatitis C virus infectionReconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer.Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase.Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli.Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4BA recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA.Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay.An adenovirus type 5 (Ad5) amplicon-based packaging cell line for production of high-capacity helper-independent deltaE1-E2-E3-E4 Ad5 vectors.trans-Complementation of flavivirus RNA polymerase gene NS5 by using Kunjin virus replicon-expressing BHK cells.Identification and characterization of an RNA-dependent RNA polymerase activity within the nonstructural protein 5B region of bovine viral diarrhea virusDe novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virusThe RNA helicase and nucleotide triphosphatase activities of the bovine viral diarrhea virus NS3 protein are essential for viral replication.De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymeraseHepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivoVirus-specific cofactor requirement and chimeric hepatitis C virus/GB virus B nonstructural protein 3Mutations in the 5' nontranslated region of bovine viral diarrhea virus result in altered growth characteristicsSpecific interaction between the hepatitis C virus NS5B RNA polymerase and the 3' end of the viral RNAMutational analysis of bovine viral diarrhea virus RNA-dependent RNA polymerase.Efficient trans-complementation of the flavivirus kunjin NS5 protein but not of the NS1 protein requires its coexpression with other components of the viral replicaseTemplate requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymeraseCharacterization of cell lines carrying self-replicating hepatitis C virus RNAs.Mutations in Hepatitis C Virus RNAs Conferring Cell Culture AdaptationEnhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations.Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: implication for viral RNA synthesis.Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication.Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymeraseMutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.Quantitative Analysis of the Hepatitis C Virus Replication ComplexDissecting the interferon-induced inhibition of hepatitis C virus replication by using a novel host cell lineStructural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with RibonucleotidesSelection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymerasePersistent and transient replication of full-length hepatitis C virus genomes in cell culture
P2860
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P2860
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Biochemical properties of hepa ...... sential for enzymatic activity
@ast
Biochemical properties of hepa ...... sential for enzymatic activity
@en
Biochemical properties of hepa ...... sential for enzymatic activity
@nl
type
label
Biochemical properties of hepa ...... sential for enzymatic activity
@ast
Biochemical properties of hepa ...... sential for enzymatic activity
@en
Biochemical properties of hepa ...... sential for enzymatic activity
@nl
prefLabel
Biochemical properties of hepa ...... sential for enzymatic activity
@ast
Biochemical properties of hepa ...... sential for enzymatic activity
@en
Biochemical properties of hepa ...... sential for enzymatic activity
@nl
P2093
P2860
P3181
P1433
P1476
Biochemical properties of hepa ...... sential for enzymatic activity
@en
P2093
P2860
P304
P3181
P577
1997-11-01T00:00:00Z