Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B
about
Herpesvirus gB: A Finely Tuned Fusion MachineStructures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common ThemeReevaluating herpes simplex virus hemifusion.High-resolution functional profiling of a gammaherpesvirus RTA locus in the context of the viral genomeMultiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infectionInsertion mutations in herpes simplex virus 1 glycoprotein H reduce cell surface expression, slow the rate of cell fusion, or abrogate functions in cell fusion and viral entry.Low pH-induced conformational change in herpes simplex virus glycoprotein B.Syncytial phenotype of C-terminally truncated herpes simplex virus type 1 gB is associated with diminished membrane interactions.Amino acid differences in glycoproteins B (gB), C (gC), H (gH) and L (gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor α.Herpes virus fusion and entry: a story with many characters.Reversible conformational change in herpes simplex virus glycoprotein B with fusion-from-without activity is triggered by mildly acidic pH.Impact of valency of a glycoprotein B-specific monoclonal antibody on neutralization of herpes simplex virusDifferential effects on cell fusion activity of mutations in herpes simplex virus 1 glycoprotein B (gB) dependent on whether a gD receptor or a gB receptor is overexpressedCross talk among the glycoproteins involved in herpes simplex virus entry and fusion: the interaction between gB and gH/gL does not necessarily require gD.Functional fluorescent protein insertions in herpes simplex virus gB report on gB conformation before and after execution of membrane fusion.Fusing structure and function: a structural view of the herpesvirus entry machinery.Herpes B virus utilizes human nectin-1 but not HVEM or PILRα for cell-cell fusion and virus entry.Using a split luciferase assay (SLA) to measure the kinetics of cell-cell fusion mediated by herpes simplex virus glycoproteins.The membrane-proximal region (MPR) of herpes simplex virus gB regulates association of the fusion loops with lipid membranes.Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B.Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesisDual split protein-based fusion assay reveals that mutations to herpes simplex virus (HSV) glycoprotein gB alter the kinetics of cell-cell fusion induced by HSV entry glycoproteinsInsertional mutations in herpes simplex virus type 1 gL identify functional domains for association with gH and for membrane fusion.Herpes simplex virus infects most cell types in vitro: clues to its successDominant-negative proteins in herpesviruses - from assigning gene function to intracellular immunization.The fusion loops and membrane proximal region of Epstein-Barr virus glycoprotein B (gB) can function in the context of herpes simplex virus 1 gB when substituted individually but not in combination.Structure-based mutational analysis of the highly conserved domain IV of glycoprotein H of pseudorabies virus.Residues within the C-terminal arm of the herpes simplex virus 1 glycoprotein B ectodomain contribute to its refolding during the fusion step of virus entry.Fusion-deficient insertion mutants of herpes simplex virus type 1 glycoprotein B adopt the trimeric postfusion conformation.Mutagenesis of varicella-zoster virus glycoprotein B: putative fusion loop residues are essential for viral replication, and the furin cleavage motif contributes to pathogenesis in skin tissue in vivo.Herpes simplex virus Membrane Fusion.Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage.Interplay between the Herpes Simplex Virus 1 gB Cytodomain and the gH Cytotail during Cell-Cell Fusion.A Functional Interaction between Herpes Simplex Virus 1 Glycoprotein gH/gL Domains I and II and gD Is Defined by Using Alphaherpesvirus gH and gL Chimeras.The Ig-like v-type domain of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion.Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor alpha depends on specific sialylated O-linked glycans on gBSubstitution of herpes simplex virus 1 entry glycoproteins with those of saimiriine herpesvirus 1 reveals a gD-gH/gL functional interaction and a region within the gD profusion domain that is critical for fusion.Membrane requirement for folding of the herpes simplex virus 1 gB cytodomain suggests a unique mechanism of fusion regulation.Mutations in the cytoplasmic tail of herpes simplex virus 1 gH reduce the fusogenicity of gB in transfected cells.Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function.
P2860
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P2860
Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
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2007年论文
@wuu
name
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@ast
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@en
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@nl
type
label
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@ast
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@en
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@nl
prefLabel
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@ast
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@en
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@nl
P2860
P356
P1476
Random linker-insertion mutage ...... ex virus type 1 glycoprotein B
@en
P2093
Patricia G Spear
P2860
P304
P356
10.1073/PNAS.0705926104
P407
P577
2007-08-07T00:00:00Z