Characterization of Fusion Determinants Points to the Involvement of Three Discrete Regions of Both E1 and E2 Glycoproteins in the Membrane Fusion Process of Hepatitis C Virus - Wikidata - wikimedia - TriplyDB

Characterization of Fusion Determinants Points to the Involvement of Three Discrete Regions of Both E1 and E2 Glycoproteins in the Membrane Fusion Process of Hepatitis C Virus

Characterization of Fusion Determinants Points to the Involvement of Three Discrete Regions of Both E1 and E2 Glycoproteins in the Membrane Fusion Process of Hepatitis C Virus

http://www.wikidata.org/entity/Q27481024

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Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains Recent advances in understanding hepatitis C Roles of lipoprotein receptors in the entry of hepatitis C virus Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization The hepatitis C virus glycan shield and evasion of the humoral immune response Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 binding CD81 and Claudin 1 Coreceptor Association: Role in Hepatitis C Virus Entry Interaction of the Most Membranotropic Region of the HCV E2 Envelope Glycoprotein with Membranes. Biophysical Characterization Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection Low pH-dependent Hepatitis C Virus Membrane Fusion Depends on E2 Integrity, Target Lipid Composition, and Density of Virus Particles A computational approach identifies two regions of Hepatitis C Virus E1 protein as interacting domains involved in viral fusion process Hepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes Mutagenesis of the fusion peptide-like domain of hepatitis C virus E1 glycoprotein: involvement in cell fusion and virus entry Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell-culture-derived H77/JFH1 chimeric infectious virus particles The Disulfide Bonds in Glycoprotein E2 of Hepatitis C Virus Reveal the Tertiary Organization of the Molecule Identification of New Functional Regions in Hepatitis C Virus Envelope Glycoprotein E2 Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2 A novel small molecule inhibitor of hepatitis C virus entry Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate Fusogenic properties of the ectodomains of hepatitis C virus envelope proteins.Unexpected structural features of the hepatitis C virus envelope protein 2 ectodomain.Capitalizing on knowledge of hepatitis C virus neutralizing epitopes for rational vaccine design The missing pieces of the HCV entry puzzle.Hepatitis C virus experimental model systems and antiviral drug research.Identification of conserved residues in hepatitis C virus envelope glycoprotein E2 that modulate virus dependence on CD81 and SRB1 entry factors.The Humoral Immune Response to HCV: Understanding is Key to Vaccine Development.Designing and Development of a DNA Vaccine Based On Structural Proteins of Hepatitis C Virus Potential treatment options and future research to increase hepatitis C virus treatment response rate Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes.Functional characterization of nuclear localization and export signals in hepatitis C virus proteins and their role in the membranous web.Hepatitis C virus life cycle and lipid metabolism Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection.Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 contain reduced cysteine residues essential for virus entry.Hepatitis C virus E1 envelope glycoprotein interacts with apolipoproteins in facilitating entry into hepatocytes.Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.New Insights into the Understanding of Hepatitis C Virus Entry and Cell-to-Cell Transmission by Using the Ionophore Monensin A.

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P2860

Characterization of Fusion Determinants Points to the Involvement of Three Discrete Regions of Both E1 and E2 Glycoproteins in the Membrane Fusion Process of Hepatitis C Virus

http://www.wikidata.org/entity/Q27481024

description

2007 nî lūn-bûn

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2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2007 թվականի օգոստոսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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Characterization of Fusion Det ...... n Process of Hepatitis C Virus

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Characterization of Fusion Det ...... n Process of Hepatitis C Virus

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Characterization of Fusion Det ...... n Process of Hepatitis C Virus

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Characterization of Fusion Det ...... n Process of Hepatitis C Virus

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Characterization of Fusion Det ...... n Process of Hepatitis C Virus

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Characterization of Fusion Det ...... n Process of Hepatitis C Virus

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Characterization of Fusion Det ...... n Process of Hepatitis C Virus

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Eve-Isabelle Pécheur

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Jennifer Molle

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Judith Fresquet

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Marlène Dreux

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Peggy Donot

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Romuald Corbau

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P2860

Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81.

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes

Functional analysis of cell surface-expressed hepatitis C virus E2 glycoprotein.

Mutational Evidence for an Internal Fusion Peptide in Flavivirus Envelope Protein E

Conservation of the Conformation and Positive Charges of Hepatitis C Virus E2 Envelope Glycoprotein Hypervariable Region 1 Points to a Role in Cell Attachment

An Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection against Neutralizing Antibodies

Role of N-linked glycans in the functions of hepatitis C virus envelope glycoproteins.

Robust hepatitis C virus infection in vitro.

Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry

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8752-65

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10.1128/JVI.02642-06

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16

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81

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François-Loïc Cosset

François Penin

Dimitri Lavillette

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2007-08-01T00:00:00Z

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6298072

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17537855

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membrane fusion involved in viral entry into host cell

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1951381

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