Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model - Wikidata - wikimedia - TriplyDB

Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

http://www.wikidata.org/entity/Q27484513

about

miR-122 continues to blaze the trail for microRNA therapeutics Mouse Systems to Model Hepatitis C Virus Treatment and Associated Resistance Relative Replication Capacity and Selective Advantage Profiles of Protease Inhibitor-Resistant Hepatitis C Virus (HCV) NS3 Protease Mutants in the HCV Genotype 1b Replicon System Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women 1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection Hepatitis C virus' Achilles' heel--dependence on liver-specific microRNA miR-122.Therapeutic implications of hepatitis C virus resistance to antiviral drugs.Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy.Experimental models for hepatitis C viral infection.Infectivity in chimpanzees (Pan troglodytes) of plasma collected before HCV RNA detectability by FDA-licensed assays: implications for transfusion safety and HCV infection outcomes Resistance mechanisms in HCV: from evolution to intervention.Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection.Non-nucleoside inhibitors of hepatitis C virus polymerase: current progress and future challenges.Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development.Antiviral therapy for hepatitis C virus: beyond the standard of care.Structure-activity relationships in the development of allosteric hepatitis C virus RNA-dependent RNA polymerase inhibitors: ten years of research.Comparative study of the genetic barriers and pathways towards resistance of selective inhibitors of hepatitis C virus replication.Screening of hepatitis C virus inhibitors using genotype 1a HCV replicon cell lines.Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials.Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects.The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis.Animal Models to Study Hepatitis C Virus Infection.

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P2860

Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

http://www.wikidata.org/entity/Q27484513

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

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2007年論文

@zh-hant

2007年論文

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2007年論文

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2007年論文

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2007年论文

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Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

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Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

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Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

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Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

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Antimicrobial Agents and Chemotherapy

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Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

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Akhteruzzaman Molla

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Chih-Ming Chen

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Dale J Kempf

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Daniel P Larson

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David W A Beno

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Hock Ben Lim

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Liangjun Lu

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Lisa E Hernandez

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Michelle A Long

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Rakesh L Tripathi

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P2860

Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration

Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.

Antiviral effect and virus-host interactions in response to alpha interferon, gamma interferon, poly(i)-poly(c), tumor necrosis factor alpha, and ribavirin in hepatitis C virus subgenomic replicons.

Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro

Lack of response to exogenous interferon-α in the liver of chimpanzees chronically infected with hepatitis C virus

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

Hepatitis C virus infection

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

The chimpanzee model of hepatitis C virus infections.

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scholarly article

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581151

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10.1128/AAC.00723-07

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Akhteruzzaman Molla

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