Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells
about
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.Mechanisms of HIV protein degradation into epitopes: implications for vaccine designThe ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residuesThe Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine DesignCTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitopeThe internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum.The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Study of antigen-processing steps reveals preferences explaining differential biological outcomes of two HLA-A2-restricted immunodominant epitopes from human immunodeficiency virus type 1.Immuno-informatics: Mining genomes for vaccine components.Post-proteasomal antigen processing for major histocompatibility complex class I presentation.The processing of antigens delivered as DNA vaccines.The role of insulin-regulated aminopeptidase in MHC class I antigen presentation.Portable flanking sequences modulate CTL epitope processing.Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.Complexity, contradictions, and conundrums: studying post-proteasomal proteolysis in HLA class I antigen presentation.Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes.Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.The design and implementation of the immune epitope database and analysis resource.Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.A long N-terminal-extended nested set of abundant and antigenic major histocompatibility complex class I natural ligands from HIV envelope protein.Calreticulin promotes folding of functional human leukocyte antigen class I molecules in vitro.A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides.The final cut: how ERAP1 trims MHC ligands to size.Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.
P2860
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P2860
Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Human transporters associated ...... um and presentation to T cells
@ast
Human transporters associated ...... um and presentation to T cells
@en
Human transporters associated ...... um and presentation to T cells
@nl
type
label
Human transporters associated ...... um and presentation to T cells
@ast
Human transporters associated ...... um and presentation to T cells
@en
Human transporters associated ...... um and presentation to T cells
@nl
prefLabel
Human transporters associated ...... um and presentation to T cells
@ast
Human transporters associated ...... um and presentation to T cells
@en
Human transporters associated ...... um and presentation to T cells
@nl
P2093
P2860
P356
P1476
Human transporters associated ...... um and presentation to T cells
@en
P2093
F V Chisari
G Niedermann
M Ostankovitch
P M van Endert
P2860
P304
P356
10.1084/JEM.190.9.1227
P407
P577
1999-11-01T00:00:00Z