Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants
about
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analysesBinding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bondingStructure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors.Molecular docking studies of marine diterpenes as inhibitors of wild-type and mutants HIV-1 reverse transcriptase.Cross-linking of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase to template-primer6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase.N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and IntegraseNew anti-HIV agents and targets.Clinical utility of current NNRTIs and perspectives of new agents in this class under development.6-(3,5-Dimethyl-benz-yl)-5-ethyl-1-[(2-phenyl-eth-oxy)meth-yl]pyrimidine-2,4(1H,3H)dione6-Chloro-1-({[(2E)-2-methyl-3-phenyl-prop-2-en-1-yl]-oxy}meth-yl)-1,2,3,4-tetra-hydro-quinazoline-2,4-dione.1-{[(2,3-Dihydro-1H-inden-2-yl)-oxy]meth-yl}quinazoline-2,4(1H,3H)-dione.Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNAArylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors.6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2).Comparative study of non nucleoside inhibitors with HIV-1 reverse transcriptase based on 3D-QSAR and docking.Three-drug combinations of emivirine and nucleoside reverse transcriptase inhibitors in vitro: long-term culture of HIV-1-infected cells and breakthrough viruses.6-Methyl-1-({[(2E)-2-methyl-3-phenyl-prop-2-en-1-yl]-oxy}meth-yl)-1,2,3,4-tetra-hydro-quinazoline-2,4-dione.Synthesis of novel 2-(substituted amino)alkylthiopyrimidin-4(3H)-ones as potential antimicrobial agents.Nucleoside analogues exerting antiviral activity through a non-nucleoside mechanism.Antiviral activity of 4-benzyl pyridinone derivatives as HIV-1 reverse transcriptase inhibitors.
P2860
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P2860
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@ast
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@en
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@nl
type
label
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@ast
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@en
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@nl
prefLabel
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@ast
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@en
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@nl
P2093
P356
P1476
Design of MKC-442 (emivirine) ...... nst drug-resistant HIV mutants
@en
P2093
P304
P356
10.1021/JM990192C
P407
P50
P577
1999-11-04T00:00:00Z