A novel endonuclease mechanism directly visualized for I-PpoI
about
Mutagenesis identifies the critical amino acid residues of human endonuclease G involved in catalysis, magnesium coordination, and substrate specificityStructure and function of type II restriction endonucleasesStructural, functional and evolutionary relationships between homing endonucleases and proteins from their host organismsMetal ions and phosphate binding in the H-N-H motif: Crystal structures of the nuclease domain of ColE7/Im7 in complex with a phosphate ion and different divalent metal ionsDNA binding and cleavage by the periplasmic nuclease Vvn: a novel structure with a known active siteCrystal structure of the -Me type II restriction endonuclease Hpy99I with target DNADNA intercalation without flipping in the specific ThaI-DNA complexHpy188I-DNA pre- and post-cleavage complexes--snapshots of the GIY-YIG nuclease mediated catalysisConserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair EnzymesStructural Insights into Apoptotic DNA Degradation by CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegansStructural Characterization of H-1 Parvovirus: Comparison of Infectious Virions to Empty CapsidsMycobacterium tuberculosis RecA intein possesses a novel ATP-dependent site-specific double-stranded DNA endonuclease activityCofactor requirement of HpyAV restriction endonucleaseStructural insights into the first incision reaction during nucleotide excision repairHoming endonucleases: structural and functional insight into the catalysts of intron/intein mobilityAltered target site specificity variants of the I-PpoI His-Cys box homing endonuclease.The zinc ion in the HNH motif of the endonuclease domain of colicin E7 is not required for DNA binding but is essential for DNA hydrolysis.Type II restriction endonucleases--a historical perspective and moreDivalent metal ion differentially regulates the sequential nicking reactions of the GIY-YIG homing endonuclease I-BmoI.The use of divalent metal ions by type II topoisomerases.Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanismStructural basis for stable DNA complex formation by the caspase-activated DNase.Genetic organization and molecular analysis of the EcoVIII restriction-modification system of Escherichia coli E1585-68 and its comparison with isospecific homologs.Treble clef finger--a functionally diverse zinc-binding structural motifStructural characterization of the late competence protein ComFB from Bacillus subtilis.Comprehensive homing endonuclease target site specificity profiling reveals evolutionary constraints and enables genome engineering applications.Crystal structural analysis and metal-dependent stability and activity studies of the ColE7 endonuclease domain in complex with DNA/Zn2+ or inhibitor/Ni2+Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.An equivalent metal ion in one- and two-metal-ion catalysisCrystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer.R.KpnI, an HNH superfamily REase, exhibits differential discrimination at non-canonical sequences in the presence of Ca2+ and Mg2+.Identification of functionally relevant histidine residues in the apoptotic nuclease CAD.Biochemical characterization of I-CmoeI reveals that this H-N-H homing endonuclease shares functional similarities with H-N-H colicinsMutagenic scan of the H-N-H motif of colicin E9: implications for the mechanistic enzymology of colicins, homing enzymes and apoptotic endonucleases.Engineering nicking enzymes that preferentially nick 5-methylcytosine-modified DNA.Type II restriction endonuclease R.KpnI is a member of the HNH nuclease superfamilyTetrameric restriction enzymes: expansion to the GIY-YIG nuclease family.The protein gp74 from the bacteriophage HK97 functions as a HNH endonuclease.Homing endonucleases from mobile group I introns: discovery to genome engineering.Identification of a single HNH active site in type IIS restriction endonuclease Eco31I.
P2860
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P2860
A novel endonuclease mechanism directly visualized for I-PpoI
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A novel endonuclease mechanism directly visualized for I-PpoI
@ast
A novel endonuclease mechanism directly visualized for I-PpoI
@en
A novel endonuclease mechanism directly visualized for I-PpoI
@nl
type
label
A novel endonuclease mechanism directly visualized for I-PpoI
@ast
A novel endonuclease mechanism directly visualized for I-PpoI
@en
A novel endonuclease mechanism directly visualized for I-PpoI
@nl
prefLabel
A novel endonuclease mechanism directly visualized for I-PpoI
@ast
A novel endonuclease mechanism directly visualized for I-PpoI
@en
A novel endonuclease mechanism directly visualized for I-PpoI
@nl
P2093
P356
P1476
A novel endonuclease mechanism directly visualized for I-PpoI
@en
P2093
P304
P356
10.1038/70027
P577
1999-12-01T00:00:00Z