Structure of Cdc42 bound to the GTPase binding domain of PAK
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Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BADThe semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent mannerSmall molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain.Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding siteMolecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)Alternative splicing of Rac1 generates Rac1b, a self-activating GTPaseCrystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKsEffector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42A Conformational Switch in the CRIB-PDZ Module of Par-6Structure ofSalmonellaEffector Protein SopB N-terminal Domain in Complex with Host Rho GTPase Cdc42Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectorsCdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20.Signaling, Regulation, and Specificity of the Type II p21-activated KinasesThe mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activityStructural basis for the signaling specificity of RhoG and Rac1 GTPasesIdentification of the region in Cdc42 that confers the binding specificity to activated Cdc42-associated kinaseThe Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1)p21-Activated kinase 4 promotes prostate cancer progression through CREBPAK as a therapeutic target in gastric cancerProtein kinase CK2 phosphorylates and activates p21-activated kinase 1Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domainYeast osmosensors Hkr1 and Msb2 activate the Hog1 MAPK cascade by different mechanisms.3D structure analysis of PAKs: A clue to the rational design for affinity reagents and blockers.Physical mechanisms of signal integration by WASP family proteins.Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration.Interactions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding.The Cdc42 binding and scaffolding activities of the fission yeast adaptor protein Scd2.A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACKEphA4 signaling regulates blastomere adhesion in the Xenopus embryo by recruiting Pak1 to suppress Cdc42 functionA large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.CDC42 is required for polarized growth in human pathogen Candida albicans.Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIXRac GTPases control axon growth, guidance and branching.Redesign of the PAK1 autoinhibitory domain for enhanced stability and affinity in biosensor applications.Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.Conformational display: a role for switch polymorphism in the superfamily of regulatory GTPases.Genetic analysis of the interface between Cdc42p and the CRIB domain of Ste20p in Saccharomyces cerevisiae
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P2860
Structure of Cdc42 bound to the GTPase binding domain of PAK
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Structure of Cdc42 bound to the GTPase binding domain of PAK
@ast
Structure of Cdc42 bound to the GTPase binding domain of PAK
@en
Structure of Cdc42 bound to the GTPase binding domain of PAK
@nl
type
label
Structure of Cdc42 bound to the GTPase binding domain of PAK
@ast
Structure of Cdc42 bound to the GTPase binding domain of PAK
@en
Structure of Cdc42 bound to the GTPase binding domain of PAK
@nl
prefLabel
Structure of Cdc42 bound to the GTPase binding domain of PAK
@ast
Structure of Cdc42 bound to the GTPase binding domain of PAK
@en
Structure of Cdc42 bound to the GTPase binding domain of PAK
@nl
P2093
P3181
P356
P1476
Structure of Cdc42 bound to the GTPase binding domain of PAK
@en
P2093
P2888
P3181
P356
10.1038/75158
P577
2000-05-01T00:00:00Z
P6179
1052762242