The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity
about
Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactionsGranzymes: a family of lymphocyte granule serine proteasesProbing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptidesCrystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residueThe Serine Protease Domain of MASP-3: Enzymatic Properties and Crystal Structure in Complex with EcotinSerglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storageCharacterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificityHow immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolutionGranzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells.Catalytic reaction mechanism of acetylcholinesterase determined by Born-Oppenheimer ab initio QM/MM molecular dynamics simulations.Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut.Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Design Parameters for Granzyme-Mediated Cytotoxic Lymphocyte Target-Cell Killing and Specificity.Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune responseAutoantigens: the critical partner in initiating and propagating systemic autoimmunity.Conversion of trypsin to a functional threonine proteaseA Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense.Mechanisms of granule-dependent killing.Expression of multiple granzymes by cytotoxic T lymphocyte implies that they activate diverse apoptotic pathways in target cells.Glutamyl Endopeptidases: The Puzzle of Substrate SpecificityA novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite.Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs.Hip is a pro-survival substrate of granzyme B.MFPred: Rapid and accurate prediction of protein-peptide recognition multispecificity using self-consistent mean field theory.Quantitative Correlation of Conformational Binding Enthalpy with Substrate Specificity of Serine Proteases.Block-based characterization of protease specificity from substrate sequence profile.Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop.The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.Global substrate specificity profiling of post-translational modifying enzymes.Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway.Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.T cells from indolent CLL patients prevent apoptosis of leukemic B cells in vitro and have altered gene expression profile.
P2860
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P2860
The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity
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2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
The structure of the pro-apopt ...... eterminants of its specificity
@ast
The structure of the pro-apopt ...... eterminants of its specificity
@en
The structure of the pro-apopt ...... eterminants of its specificity
@nl
type
label
The structure of the pro-apopt ...... eterminants of its specificity
@ast
The structure of the pro-apopt ...... eterminants of its specificity
@en
The structure of the pro-apopt ...... eterminants of its specificity
@nl
prefLabel
The structure of the pro-apopt ...... eterminants of its specificity
@ast
The structure of the pro-apopt ...... eterminants of its specificity
@en
The structure of the pro-apopt ...... eterminants of its specificity
@nl
P2093
P356
P1476
The structure of the pro-apopt ...... eterminants of its specificity
@en
P2093
J L Harris
R Fletterick
P356
10.1038/78992
P577
2000-09-01T00:00:00Z