Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases
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Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradationHuman EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteinsEDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complexA novel ER alpha-mannosidase-like protein accelerates ER-associated degradationStructure of Penicillium citrinum alpha 1,2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and Golgi class I enzymesStructure of Kre2p/Mnt1p: a yeast alpha1,2-mannosyltransferase involved in mannoprotein biosynthesisModulation of activity by Arg407: structure of a fungal α-1,2-mannosidase in complex with a substrate analogueDivergence of Catalytic Mechanism within a Glycosidase Family Provides Insight into Evolution of Carbohydrate Metabolism by Human Gut FloraMechanistic insights into a Ca2+-dependent family of α-mannosidases in a human gut symbiontStructural and mechanistic insight into N-glycan processing by endo-α-mannosidaseSequence-dependent effects of cryoprotectants on the active sites of the human ABO(H) blood group A and B glycosyltransferasesThe reaction coordinate of a bacterial GH47 α-mannosidase: a combined quantum mechanical and structural approachArms Race between Enveloped Viruses and the Host ERAD MachineryA novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradationAllosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivityRespiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturationEDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimmingUnderstanding protein structure-function relationships in Family 47 alpha-1,2-mannosidases through computational docking of ligands.A Golgi-localized mannosidase (MAN1B1) plays a non-enzymatic gatekeeper role in protein biosynthetic quality control.Glycosidase inhibitors: a patent review (2008-2013).Energetics of substrate binding and catalysis by class 1 (glycosylhydrolase family 47) alpha-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control.Characterization of Schizosaccharomyces pombe ER alpha-mannosidase: a reevaluation of the role of the enzyme on ER-associated degradationProduction of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells.A hydrophobic platform as a mechanistically relevant transition state stabilising factor appears to be present in the active centre of all glycoside hydrolases.Chemoenzymatic synthesis and Fcγ receptor binding of homogeneous glycoforms of antibody Fc domain. Presence of a bisecting sugar moiety enhances the affinity of Fc to FcγIIIa receptor.Characterization of an extracellularly derived α-mannosidase from the liquid exudate of the sclerotia of Sclerotinia sclerotiorum (Lib.) de Bary.ERManI (Endoplasmic Reticulum Class I α-Mannosidase) Is Required for HIV-1 Envelope Glycoprotein Degradation via Endoplasmic Reticulum-associated Protein Degradation PathwayN-linked glycan recognition and processing: the molecular basis of endoplasmic reticulum quality controlHtm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation.Structural glycobiology: a game of snakes and ladders.Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1-neutralizing activity.Selective exo-enzymatic labeling of N-glycans on the surface of living cells by recombinant ST6Gal ISubstrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.Family 47 alpha-mannosidases in N-glycan processing.Human endoplasmic reticulum mannosidase I is subject to regulated proteolysis.Convergent and divergent mechanisms of sugar recognition across kingdoms.The alpha(1,2)-mannosidase I inhibitor 1-deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120.Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases.Emerging structural insights into glycoprotein quality control coupled with N-glycan processing in the endoplasmic reticulum.Identification of catalytic residues of Ca2+-independent 1,2-alpha-D-mannosidase from Aspergillus saitoi by site-directed mutagenesis.
P2860
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P2860
Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
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2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@ast
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@en
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@nl
type
label
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@ast
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@en
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@nl
prefLabel
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@ast
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@en
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@nl
P2093
P2860
P3181
P356
P1476
Structural basis for catalysis ...... class I alpha 1,2-mannosidases
@en
P2093
A Herscovics
K W Moremen
P L Howell
P2860
P304
P3181
P356
10.1074/JBC.M006927200
P407
P577
2000-12-29T00:00:00Z