Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme
about
Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolasesMimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activityConserved main-chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthaseStructure of anEscherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 Å resolutionStructural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed EvolutionIdentification of biochemical and putative biological role of a xenolog from Escherichia coli using structural analysisStructural Insights into the Recovery of Aldolase Activity inN-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with γ-Thialysine by Using a Chemical Mutagenesis StrategyStructural Basis for Substrate Specificity and Mechanism of N -Acetyl- d -neuraminic Acid Lyase from Pasteurella multocidaReaction Mechanism of N -Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and MutagenesisIdentification of the bona fide DHDPS from a common plant pathogenCharacterization of a novel N-acetylneuraminic acid lyase favoring N-acetylneuraminic acid synthesisIdentification of aldolase and ferredoxin reductase within the dbt operon of Burkholderia fungorum DBT1.Patterns of evolutionary conservation of essential genes correlate with their compensabilityModulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251.Computational tools for rational protein engineering of aldolases.First functional and mutational analysis of group 3 N-acetylneuraminate lyases from Lactobacillus antri and Lactobacillus sakei 23KL-Hydroxyproline and d-Proline Catabolism in Sinorhizobium melilotiPreliminary crystallographic analysis of L-2-keto-3-deoxyarabonate dehydratase, an enzyme involved in an alternative bacterial pathway of L-arabinose metabolism.Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.Pasteurella multocida sialic acid aldolase: a promising biocatalystDirected evolution of aldolases for exploitation in synthetic organic chemistryCloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine-6-phosphate 2-epimerase from methicillin-resistant Staphylococcus aureusCloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine kinase from methicillin-resistant Staphylococcus aureus.Purification, crystallization and preliminary crystallographic analysis of human dihydrodipicolinate synthase-like protein (DHDPSL).Molecular characterization of a novel N-acetylneuraminate lyase from Lactobacillus plantarum WCFS1.Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol.Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.Characterization and mutagenesis of the recombinant N-acetylneuraminate lyase from Clostridium perfringens: insights into the reaction mechanism.The sialate-pyruvate lyase from pig kidney. Elucidation of the primary structure and expression of recombinant enzyme activity.Eukaryotic and bacterial gene clusters related to an alternative pathway of nonphosphorylated L-rhamnose metabolism.Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis.The role of a conserved histidine residue in a pyruvate-specific Class II aldolase.Identification and characterization of L-arabonate dehydratase, L-2-keto-3-deoxyarabonate dehydratase, and L-arabinolactonase involved in an alternative pathway of L-arabinose metabolism. Novel evolutionary insight into sugar metabolism.A novel alpha-ketoglutaric semialdehyde dehydrogenase: evolutionary insight into an alternative pathway of bacterial L-arabinose metabolism.Molecular Characterization of a Novel N-Acetylneuraminate Lyase from a Deep-Sea Symbiotic Mycoplasma.
P2860
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P2860
Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Active site modulation in the ...... Haemophilus influenzae enzyme
@ast
Active site modulation in the ...... Haemophilus influenzae enzyme
@en
Active site modulation in the ...... Haemophilus influenzae enzyme
@nl
type
label
Active site modulation in the ...... Haemophilus influenzae enzyme
@ast
Active site modulation in the ...... Haemophilus influenzae enzyme
@en
Active site modulation in the ...... Haemophilus influenzae enzyme
@nl
prefLabel
Active site modulation in the ...... Haemophilus influenzae enzyme
@ast
Active site modulation in the ...... Haemophilus influenzae enzyme
@en
Active site modulation in the ...... Haemophilus influenzae enzyme
@nl
P2093
P356
P1476
Active site modulation in the ...... Haemophilus influenzae enzyme
@en
P2093
J A Barbosa
M C Lawrence
R Brossmer
S M Marcuccio
W R Jackson
P304
P356
10.1006/JMBI.2000.4138
P407
P577
2000-10-27T00:00:00Z