Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 A resolution
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Unusual conformational changes in 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as revealed by X-ray crystallography and NMRStructural characterization of CA1462, the Candida albicans thiamine pyrophosphokinaseCrystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensisBisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved propertiesStructure of S. aureus HPPK and the Discovery of a New Substrate Site InhibitorExploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPKBisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding modeThe identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinaseStructural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensisThe human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamineMg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporterPhosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.Ferreting out correlations from trajectory data.Loop conformation and dynamics of the Escherichia coli HPPK apo-enzyme and its binary complex with MgATPThe folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery.New ways to derivatize at position 6 of 7,7-dimethyl-7,8-dihydropterin.Role of protein conformational dynamics in the catalysis by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinaseExperimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB).Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities.Kinetic and structural characterization of a product complex of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Escherichia coli.Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase.Molecular motions and conformational changes of HPPK.A three-component signalling system fine-tunes expression kinetics of HPPK responsible for folate synthesis by positive feedback loop during stress response of Xanthomonas campestris.Pyrithiamine as a substrate for thiamine pyrophosphokinase.Manipulating and probing enzymatic conformational fluctuations and enzyme-substrate interactions by single-molecule FRET-magnetic tweezers microscopy.
P2860
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P2860
Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 A resolution
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2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@ast
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@en
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@nl
type
label
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@ast
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@en
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@nl
prefLabel
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@ast
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@en
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@nl
P2093
P3181
P1433
P1476
Catalytic center assembly of H ...... y complex at 1.25 A resolution
@en
P2093
P304
P3181
P356
10.1016/S0969-2126(00)00502-5
P50
P577
2000-10-01T00:00:00Z