Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase
about
Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammalsLysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancerM-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemiaConservation of structure and activity in Plasmodium purine nucleoside phosphorylasesStructure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDSStructural characterization of the apo form and NADH binary complex of human lactate dehydrogenaseStructures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound formsProteopedia: Rossmann fold: A beta-alpha-beta fold at dinucleotide binding sitesTriple Isotope Effects Support Concerted Hydride and Proton Transfer and Promoting Vibrations in Human Heart Lactate DehydrogenaseRedox specificity of 2-hydroxyacid-coupled NAD(+)/NADH dehydrogenases: a study exploiting "reactive" arginine as a reporter of protein electrostatics.Enzyme sequence and its relationship to hyperbaric stability of artificial and natural fish lactate dehydrogenases.The promoting vibration in human heart lactate dehydrogenase is a preferred vibrational channelHuman lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function.Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTG1).Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.The enzymatic reaction catalyzed by lactate dehydrogenase exhibits one dominant reaction path.Slow conformational motions that favor sub-picosecond motions important for catalysis.Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody.Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs.A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolismInhibition of lactate dehydrogenase activity as an approach to cancer therapy.Ionic strength dependence of F-actin and glycolytic enzyme associations: a Brownian dynamics simulations approach.Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.Search for Human Lactate Dehydrogenase A Inhibitors Using Structure-Based Modeling.Placental metabolic reprogramming: do changes in the mix of energy-generating substrates modulate fetal growth?A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using ÄKTAxpressTM.Reaction coordinate of an enzymatic reaction revealed by transition path sampling.Ligand binding and protein dynamics in lactate dehydrogenaseNew insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases.Targeting a Rate-Promoting Vibration with an Allosteric Mediator in Lactate Dehydrogenase.Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells.Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells.Small-molecule inhibitors of human LDH5.Enzyme active site interactions by Raman/FTIR, NMR, and ab initio calculationsThe Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor.Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis.Cancer cell behaviors mediated by dysregulated pH dynamics at a glance.The Kinetics of Enzyme Mixtures.Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways.
P2860
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P2860
Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structural basis for altered a ...... of human lactate dehydrogenase
@ast
Structural basis for altered a ...... of human lactate dehydrogenase
@en
Structural basis for altered a ...... of human lactate dehydrogenase
@nl
type
label
Structural basis for altered a ...... of human lactate dehydrogenase
@ast
Structural basis for altered a ...... of human lactate dehydrogenase
@en
Structural basis for altered a ...... of human lactate dehydrogenase
@nl
prefLabel
Structural basis for altered a ...... of human lactate dehydrogenase
@ast
Structural basis for altered a ...... of human lactate dehydrogenase
@en
Structural basis for altered a ...... of human lactate dehydrogenase
@nl
P2093
P2860
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Structural basis for altered a ...... of human lactate dehydrogenase
@en
P2093
P2860
P304
P3181
P356
10.1002/1097-0134(20010501)43:2<175::AID-PROT1029>3.0.CO;2-#
P407
P577
2001-05-01T00:00:00Z