The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12
about
The retinoid X receptors and their ligandsCrystal structure of the heterodimeric complex of LXR and RXR ligand-binding domains in a fully agonistic conformationInsights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligandsStructural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxusCoupling of receptor conformation and ligand orientation determine graded activityStructure, Energetics, and Dynamics of Binding Coactivator Peptide to the Human Retinoid X Receptor α Ligand Binding Domain Complex with 9- cis -Retinoic AcidDefining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor Ligand Binding DomainSynergic effect of vitamin A and high-fat diet in adipose tissue development and nuclear receptor expression in young ratsInvestigation of ligand interactions with human RXRalpha by hydrogen/deuterium exchange and mass spectrometry.Structural and functional insights into nuclear receptor signaling.Deciphering the nuclear bile acid receptor FXR paradigm.Ligand binding shifts highly mobile retinoid X receptor to the chromatin-bound state in a coactivator-dependent manner, as revealed by single-cell imaging.The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain.Modeling, synthesis and biological evaluation of potential retinoid X receptor-selective agonists: novel halogenated analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)Effects of LG268 on Cell Proliferation and Apoptosis of NB4 CellsA transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens.Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydroLive-cell fluorescence correlation spectroscopy dissects the role of coregulator exchange and chromatin binding in retinoic acid receptor mobility.A permissive retinoid X receptor/thyroid hormone receptor heterodimer allows stimulation of prolactin gene transcription by thyroid hormone and 9-cis-retinoic acid.Designed Spiroketal Protein Modulation.Equilibrium unfolding of the retinoid X receptor ligand binding domain and characterization of an unfolding intermediate.Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRalpha LBD.Synthetic retinoids: structure-activity relationships.Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription.Identification of ligand binding site on RXRγ using molecular docking and dynamics methods.Molecular dynamics simulations and molecular flooding studies of the retinoid X-receptor ligand binding domain.The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptorsDesigned Spiroketal Protein Modulation
P2860
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P2860
The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12
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2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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name
The structural basis for the s ...... hts into the role of helix H12
@ast
The structural basis for the s ...... hts into the role of helix H12
@en
The structural basis for the s ...... hts into the role of helix H12
@nl
type
label
The structural basis for the s ...... hts into the role of helix H12
@ast
The structural basis for the s ...... hts into the role of helix H12
@en
The structural basis for the s ...... hts into the role of helix H12
@nl
prefLabel
The structural basis for the s ...... hts into the role of helix H12
@ast
The structural basis for the s ...... hts into the role of helix H12
@en
The structural basis for the s ...... hts into the role of helix H12
@nl
P2093
P2860
P3181
P356
P1476
The structural basis for the s ...... hts into the role of helix H12
@en
P2093
James D Love
John T Gooch
John W R Schwabe
Szilvia Benko
V Krishna K Chatterjee
P2860
P304
P3181
P356
10.1074/JBC.M110869200
P407
P577
2002-03-29T00:00:00Z