The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR
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End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseSolution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineusInhibition mechanism of the acetylcholine receptor by alpha-neurotoxins as revealed by normal-mode dynamicsElectron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matriceseat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx.The neuromuscular junction: measuring synapse size, fragmentation and changes in synaptic protein density using confocal fluorescence microscopy.Snake and snail toxins acting on nicotinic acetylcholine receptors: fundamental aspects and medical applications.Computational approaches to understand alpha-conotoxin interactions at neuronal nicotinic receptors.High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays.From toxins targeting ligand gated ion channels to therapeutic molecules.Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation.An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors.Aromatic Residues {epsilon}Trp-55 and {delta}Trp-57 and the Activation of Acetylcholine Receptor Channels.Molecular dissection of Cl--selective Cys-loop receptor points to components that are dispensable or essential for channel activity.Two-dimensional measurement of proton T1rho relaxation in unlabeled proteins: mobility changes in alpha-bungarotoxin upon binding of an acetylcholine receptor peptide.Methyllycaconitine, alpha-bungarotoxin and (+)-tubocurarine block fast ATP-gated currents in rat dorsal root ganglion cells.Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors.Binding of long-chain alpha-neurotoxin would stabilize the resting state of nAChR: a comparative study with alpha-conotoxin.Structurally conserved alpha-neurotoxin genes encode functionally diverse proteins in the venom of Naja sputatrix.Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding protein.A novel pharmatope tag inserted into the beta4 subunit confers allosteric modulation to neuronal nicotinic receptors.Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor.Vesicles in snake motor terminals comprise one functional pool and utilize a single recycling strategy at all stimulus frequencies.Bacterial expression, NMR, and electrophysiology analysis of chimeric short/long-chain alpha-neurotoxins acting on neuronal nicotinic receptors.Molecular modeling and structural analysis of nAChR variants uncovers the mechanism of resistance to snake toxins.Elastic network normal mode dynamics reveal the GPCR activation mechanism.Cholinergic activity is essential for maintaining the anterograde transport of Choline Acetyltransferase in Drosophila.
P2860
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P2860
The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR
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2002 nî lūn-bûn
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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@ast
The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@en
The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@nl
type
label
The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@ast
The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@en
The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@nl
prefLabel
The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@ast
The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@en
The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@nl
P2093
P3181
P1433
P1476
The mechanism for acetylcholin ...... a-bungarotoxin revealed by NMR
@en
P2093
Abraham Samson
Jacob Anglister
Jordan Chill
Tali Scherf
P304
P3181
P356
10.1016/S0896-6273(02)00773-0
P407
P577
2002-07-18T00:00:00Z