High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate
about
Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domainsInteraction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9Protein kinases and phosphatases in the control of cell fatePhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouseAn amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machineryLipid biology of breast cancerLysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagyBinding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational changeThe Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular SwitchStructural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology DomainStructures of the pleckstrin homology domain ofSaccharomyces cerevisiaeAvo1 and its human orthologue Sin1, an essential subunit of TOR complex 2Structural Analyses of the Slm1-PH Domain Demonstrate Ligand Binding in the Non-Canonical SiteAkt2 negatively regulates assembly of the POSH-MLK-JNK signaling complexTranslation of the phosphoinositide code by PI effectorsRole of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibitionA computational approach to finding novel targets for existing drugsStructural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domainsMembrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activitySequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.Structural characterization of the split pleckstrin homology domain in phospholipase C-gamma1 and its interaction with TRPC3.Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of rho kinasesIntramolecular and intermolecular interactions of protein kinase B define its activation in vivoCa(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1.Discovery of a novel class of AKT pleckstrin homology domain inhibitors.Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral headComprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions.Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells.Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Small-molecule inhibitors of the PI3K signaling networkDocosahexaenoic acid: a positive modulator of Akt signaling in neuronal survivalEvolutionary versatility of eukaryotic protein domains revealed by their bigram networksIn vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.
P2860
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P2860
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate
description
2002 nî lūn-bûn
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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2002 թվականի հուլիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@ast
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@en
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@nl
type
label
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@ast
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@en
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@nl
prefLabel
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@ast
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@en
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@nl
P3181
P1433
P1476
High-resolution structure of t ...... inositol (3,4,5)-trisphosphate
@en
P2093
Christine C Thomas
Daan M F van Aalten
P304
P3181
P356
10.1016/S0960-9822(02)00972-7
P407
P577
2002-07-23T00:00:00Z