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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

http://www.wikidata.org/entity/Q27639943

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Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1 A guide for functional analysis of BRCA1 variants of uncertain significance Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif BRCA genetic screening in Middle Eastern and North African: mutational spectrum and founder BRCA1 mutation (c.798_799delTT) in North African Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.High occurrence of BRCA1 intragenic rearrangements in hereditary breast and ovarian cancer syndrome in the Czech Republic.Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk individuals.Mutations in the BRCT binding site of BRCA1 result in hyper-recombination Role of E542 and E545 missense mutations of PIK3CA in breast cancer: a comparative computational approach.Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.The role of BRCA1 in DNA damage response.Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.Structural basis for phosphorylation-dependent signaling in the DNA-damage response.Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?Mutation screening of the BRCA1 gene in early onset and familial breast/ovarian cancer in Moroccan population.The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.Kinetic analysis of interaction of BRCA1 tandem breast cancer c-terminal domains with phosphorylated peptides reveals two binding conformations The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1 Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.Assessment of functional effects of unclassified genetic variants.Cancer predisposing mutations in BRCT domains.Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.Candidate Gene Analysis of Breast Cancer in the Jordanian Population of Arab Descent: A Case-Control Study.BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci.Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.Detection of single amino acid mutation in human breast cancer by disordered plasmonic self-similar chain.Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants.Structural and functional characterization of the MERIT40 to understand its role in DNA repair.BRCA1 point mutations in premenopausal breast cancer patients from Central Sudan.Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail.Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations.Understanding mutations and protein stability through tripeptides.Detection of a novel mutation in exon 20 of the BRCA1 gene.

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

http://www.wikidata.org/entity/Q27639943

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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Journal of Biological Chemistry

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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

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J N Mark Glover

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R Scott Williams

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P2860

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

Structure of an XRCC1 BRCT domain: a new protein-protein interaction module

BRCA1 interacts with components of the histone deacetylase complex

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

Solution structure and backbone dynamics of the human DNA ligase IIIalpha BRCT domain

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2630-5

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scholarly article

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10.1074/JBC.M210019200

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278

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2003-01-24T00:00:00Z

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12427738

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