Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations
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Functional asymmetry in the lysyl-tRNA synthetase explored by molecular dynamics, free energy calculations and experimentIn silico discovery of aminoacyl-tRNA synthetase inhibitorsFunctional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same GeneCrystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activityCrystal Structure of Tryptophanyl-tRNA Synthetase Complexed with Adenosine-5′ Tetraphosphate: Evidence for Distributed Use of Catalytic Binding Energy in Amino Acid Activation by Class I Aminoacyl-tRNA SynthetasesFunctional and Crystal Structure Analysis of Active Site Adaptations of a Potent Anti-Angiogenic Human tRNA SynthetaseCatalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic statesIndependent saturation of three TrpRS subsites generates a partially assembled state similar to those observed in molecular simulationsCrystal Structure of a Mammalian CTP: Phosphocholine Cytidylyltransferase Catalytic Domain Reveals Novel Active Site Residues within a Highly Conserved Nucleotidyltransferase FoldCrystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug designStructure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphateCrystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase.Computational Design of Catalytic Dyads and Oxyanion Holes for Ester HydrolysisCrystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug designAn Appended Domain Results in an Unusual Architecture for Malaria Parasite Tryptophanyl-tRNA SynthetaseA novel crystal form of pyrrolysyl-tRNA synthetase reveals the pre- and post-aminoacyl-tRNA synthesis conformational states of the adenylate and aminoacyl moieties and an asparagine residue in the catalytic siteThe Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed.Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase.An Ancestral Tryptophanyl-tRNA Synthetase Precursor Achieves High Catalytic Rate Enhancement without Ordered Ground-State Tertiary Structures.High-Dimensional Mutant and Modular Thermodynamic Cycles, Molecular Switching, and Free Energy Transduction.Tryptophanyl-tRNA synthetase Urzyme: a model to recapitulate molecular evolution and investigate intramolecular complementationStructure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity.Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.Selective Inhibition of Bacterial Tryptophanyl-tRNA Synthetases by Indolmycin Is Mechanism-based.Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents.Capture and quality control mechanisms for adenosine-5'-triphosphate binding.Statistical evaluation of the Rodin-Ohno hypothesis: sense/antisense coding of ancestral class I and II aminoacyl-tRNA synthetases.Enhanced amino acid selection in fully evolved tryptophanyl-tRNA synthetase, relative to its urzyme, requires domain motion sensed by the D1 switch, a remote dynamic packing motif.Combining multi-mutant and modular thermodynamic cycles to measure energetic coupling networks in enzyme catalysis.An unusual tryptophanyl tRNA synthetase interacts with nitric oxide synthase in Deinococcus radiodurans.Emergence and evolution.Computational modeling and molecular dynamics simulations of mammalian cytoplasmic tyrosyl-tRNA synthetase and its complexes with substrates.Activation of D-tyrosine by Bacillus stearothermophilus tyrosyl-tRNA synthetase: 1. Pre-steady-state kinetic analysis reveals the mechanistic basis for the recognition of D-tyrosine.A master switch couples Mg²⁺-assisted catalysis to domain motion in B. stearothermophilus tryptophanyl-tRNA SynthetaseA conformational transition state accompanies tryptophan activation by B. stearothermophilus tryptophanyl-tRNA synthetase.Mg2+-assisted catalysis by B. stearothermophilus TrpRS is promoted by allosteric effects.Mimivirus TyrRS: preliminary structural and functional characterization of the first amino-acyl tRNA synthetase found in a virus.Thermodynamic analysis reveals a temperature-dependent change in the catalytic mechanism of bacillus stearothermophilus tyrosyl-tRNA synthetase.
P2860
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P2860
Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Interconversion of ATP binding ...... transition-state conformations
@ast
Interconversion of ATP binding ...... transition-state conformations
@en
Interconversion of ATP binding ...... transition-state conformations
@nl
type
label
Interconversion of ATP binding ...... transition-state conformations
@ast
Interconversion of ATP binding ...... transition-state conformations
@en
Interconversion of ATP binding ...... transition-state conformations
@nl
prefLabel
Interconversion of ATP binding ...... transition-state conformations
@ast
Interconversion of ATP binding ...... transition-state conformations
@en
Interconversion of ATP binding ...... transition-state conformations
@nl
P2093
P50
P1476
Interconversion of ATP binding ...... transition-state conformations
@en
P2093
Charles W Carter
Pascal Retailleau
Patrice Vachette
Valentin Ilyin
Violetta Weinreb
P356
10.1016/S0022-2836(02)01156-7
P407
P577
2003-01-03T00:00:00Z