High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4'-epimerase: a potential target for structure-based development of novel trypanocides
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Altered architecture of substrate binding region defines the unique specificity of UDP-GalNAc 4-epimerasesElucidation of substrate specificity in Aspergillus nidulans UDP-galactose-4-epimeraseThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsA multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homologyIn-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plantsIdentification of recurring protein structure microenvironments and discovery of novel functional sites around CYS residuesThe suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number.Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions.Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness.Preliminary X-ray crystallographic studies of UDP-glucose-4-epimerase from Aspergillus nidulansUDP-galactose 4'-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors.Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.The molecular dynamics of Trypanosoma brucei UDP-galactose 4'-epimerase: a drug target for African sleeping sicknessAltered cofactor binding affects stability and activity of human UDP-galactose 4'-epimerase: implications for type III galactosemiaBrUGE1 transgenic rice showed improved growth performance with enhanced drought toleranceOverlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides.Genetic basis of coaggregation receptor polysaccharide biosynthesis in Streptococcus sanguinis and related species.Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP.Gene expression patterns and catalytic properties of UDP-D-glucose 4-epimerases from barley (Hordeum vulgare L.).Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase.Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose.Biosynthesis of galactofuranose in kinetoplastids: novel therapeutic targets for treating leishmaniasis and chagas' disease.Structure/function of human type 1 3beta-hydroxysteroid dehydrogenase: An intrasubunit disulfide bond in the Rossmann-fold domain and a Cys residue in the active site are critical for substrate and coenzyme utilization.Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: substrate specificity in udp-hexose 4-epimerases.Distinct properties of the five UDP-D-glucose/UDP-D-galactose 4-epimerase isoforms of Arabidopsis thaliana.
P2860
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P2860
High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4'-epimerase: a potential target for structure-based development of novel trypanocides
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
High-resolution crystal struct ...... elopment of novel trypanocides
@ast
High-resolution crystal struct ...... elopment of novel trypanocides
@en
High-resolution crystal struct ...... elopment of novel trypanocides
@nl
type
label
High-resolution crystal struct ...... elopment of novel trypanocides
@ast
High-resolution crystal struct ...... elopment of novel trypanocides
@en
High-resolution crystal struct ...... elopment of novel trypanocides
@nl
prefLabel
High-resolution crystal struct ...... elopment of novel trypanocides
@ast
High-resolution crystal struct ...... elopment of novel trypanocides
@en
High-resolution crystal struct ...... elopment of novel trypanocides
@nl
P2093
P921
P1476
High-resolution crystal struct ...... elopment of novel trypanocides
@en
P2093
Charles S Bond
David G Gourley
Janine R Roper
Matthew P Shaw
Michael A J Ferguson
William N Hunter
P304
P356
10.1016/S0166-6851(02)00243-8
P577
2003-02-01T00:00:00Z