Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids
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Structure of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzymeCrystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and CatalysisConversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERINGProgesterone-targeted magnetic resonance imaging probesModeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.Synthesis and biological evaluation of water-soluble progesterone-conjugated probes for magnetic resonance imaging of hormone related cancersMetabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamilyInhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.A steroid-conjugated magnetic resonance probe enhances contrast in progesterone receptor expressing organs and tumors in vivo.Promiscuity and diversity in 3-ketosteroid reductases.Pre-receptor regulation of the androgen receptorSystematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancerCortisol-Metabolizing Enzymes in Polycystic Ovary Syndrome.Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens.Current physico-biochemistry in steroid research and status of structural biology for steroid-converting enzymes.Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells.Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer.Characterization of hamster NAD+-dependent 3(17)β-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily.
P2860
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P2860
Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@ast
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@en
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@nl
type
label
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@ast
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@en
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@nl
prefLabel
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@ast
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@en
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@nl
P2093
P3181
P1476
Human 20alpha-hydroxysteroid d ...... binding site for C21-steroids
@en
P2093
Fernand Labrie
Jean-François Couture
Line Cantin
Pierre Legrand
Rock Breton
Van Luu-The
P304
P3181
P356
10.1016/S0022-2836(03)00762-9
P407
P577
2003-08-15T00:00:00Z