Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor
about
Structural genomics of protein phosphatasesUtilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia pestis Outer Protein H (YopH) Phosphatase ‡Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition stateBinding-site assessment by virtual fragment screeningAutoClickChem: click chemistry in silicoDesign novel dual agonists for treating type-2 diabetes by targeting peroxisome proliferator-activated receptors with core hopping approachCharacterization of peptidyl-tRNA hydrolase encoded by open reading frame Rv1014c of Mycobacterium tuberculosis H37RvProtein pockets: inventory, shape, and comparisonDiscovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.A two stage click-based library of protein tyrosine phosphatase inhibitorsInhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages.Oxime-based click chemistry in the development of 3-isoxazolecarboxylic acid containing inhibitors of Yersinia pestis protein tyrosine phosphatase, YopH.Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus.Ugi reaction-assisted rapid assembly of affinity-based probes against potential protein tyrosine phosphatases.CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitorsA three-stage biophysical screening cascade for fragment-based drug discovery.Recent advances in protein tyrosine phosphatase 1B inhibitors.Protein-tyrosine phosphatases and cancer.Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor designOxidative stress-associated protein tyrosine kinases and phosphatases in Fanconi anemiaNew strategies in fighting TB: targeting Mycobacterium tuberculosis-secreted phosphatases MptpA & MptpB.Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.Fragment-based drug discovery using the SHAPES method.Compound Design by Fragment-Linking.Ligand efficiency indices for effective drug discovery.Novel heteroaryl phosphonicdiamides PTPs inhibitors as anti-hyperglycemic agents.Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors.Challenging the gold standard for 3D-QSAR: template CoMFA versus X-ray alignment.
P2860
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P2860
Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
name
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@ast
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@en
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@nl
type
label
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@ast
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@en
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@nl
prefLabel
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@ast
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@en
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@nl
P2093
P356
P1476
Fragment screening and assembl ...... osine phosphatase 1B inhibitor
@en
P2093
Cele Abad-Zapatero
Charles W Hutchins
Cristina M Rondinone
Deanna L Haasch
Hongyu Zhao
James M Trevillyan
Michael R Jirousek
Philip J Hajduk
Stephen J Ballaron
P304
P356
10.1021/JM034122O
P407
P577
2003-09-25T00:00:00Z