Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition
about
Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryoteA new Apicomplexa-specific protein kinase family: multiple members in Plasmodium falciparum, all with an export signatureAn evolutionary perspective on the kinome of malaria parasitesThe Cryptosporidium parvum KinomeThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsA Plasmodium falciparum transcriptional cyclin-dependent kinase-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activityInhibition of Eimeria tenella CDK-related kinase 2: From target identification to lead compounds.Quantitative trait loci mapping reveals candidate pathways regulating cell cycle duration in Plasmodium falciparum.The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum.The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmissionChemical interrogation of the malaria kinome.Selectivity and potency of cyclin-dependent kinase inhibitors.Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine.Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasites.Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites.Antimalarial drug discovery: targeting protein kinases.Heterologous expression of plasmodial proteins for structural studies and functional annotation.Molecular machinery of signal transduction and cell cycle regulation in PlasmodiumSoluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.cAMP-dependent protein kinase from Plasmodium falciparum: an update.Plasmodium kinases as targets for new-generation antimalarials.In silico three-dimensional pharmacophores for aiding the discovery of the Pfmrk (Plasmodium cyclin-dependent protein kinases) specific inhibitors for the therapeutic treatment of malaria.Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: the role of water molecules examined.Regulation of DNA replication proteins in parasitic protozoans: possible role of CDK-like kinases.Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo.Recent advances in the CRANK software suite for experimental phasingSeveral human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents.
P2860
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P2860
Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structures of P. falciparum Pf ...... s of small molecule inhibition
@ast
Structures of P. falciparum Pf ...... s of small molecule inhibition
@en
Structures of P. falciparum Pf ...... s of small molecule inhibition
@nl
type
label
Structures of P. falciparum Pf ...... s of small molecule inhibition
@ast
Structures of P. falciparum Pf ...... s of small molecule inhibition
@en
Structures of P. falciparum Pf ...... s of small molecule inhibition
@nl
prefLabel
Structures of P. falciparum Pf ...... s of small molecule inhibition
@ast
Structures of P. falciparum Pf ...... s of small molecule inhibition
@en
Structures of P. falciparum Pf ...... s of small molecule inhibition
@nl
P2093
P1433
P1476
Structures of P. falciparum Pf ...... s of small molecule inhibition
@en
P2093
Anais Merckx
Darren Burgess
Jane Endicott
Martin Noble
Simon Holton
P304
P356
10.1016/J.STR.2003.09.020
P577
2003-11-01T00:00:00Z