Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue
about
Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity'Ribozoomin'--translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs)eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core.A yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM diseaseThe eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4GEukaryotic translation initiation factor 5 is critical for integrity of the scanning preinitiation complex and accurate control of GCN4 translation.An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiationUnique classes of mutations in the Saccharomyces cerevisiae G-protein translation elongation factor 1A suppress the requirement for guanine nucleotide exchange.GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway.Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.Crystal structure of the C-terminal domain of the ɛ subunit of human translation initiation factor eIF2B.Translational control by RGS2.eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.eIF5 is a dual function GAP and GDI for eukaryotic translational control.A new function and complexity for protein translation initiation factor eIF2BArchitecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.Crystal structure of eIF2B and insights into eIF2-eIF2B interactions.eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B.Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation.Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.Direct binding of translation initiation factor eIF2gamma-G domain to its GTPase-activating and GDP-GTP exchange factors eIF5 and eIF2B epsilon.Physical association of eukaryotic initiation factor (eIF) 5 carboxyl-terminal domain with the lysine-rich eIF2beta segment strongly enhances its binding to eIF3.
P2860
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P2860
Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue
description
2004 nî lūn-bûn
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2004 թուականի Մարտին հրատարակուած գիտական յօդուած
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2004 թվականի մարտին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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name
Structure of the catalytic fra ...... ly important catalytic residue
@ast
Structure of the catalytic fra ...... ly important catalytic residue
@en
Structure of the catalytic fra ...... ly important catalytic residue
@nl
type
label
Structure of the catalytic fra ...... ly important catalytic residue
@ast
Structure of the catalytic fra ...... ly important catalytic residue
@en
Structure of the catalytic fra ...... ly important catalytic residue
@nl
prefLabel
Structure of the catalytic fra ...... ly important catalytic residue
@ast
Structure of the catalytic fra ...... ly important catalytic residue
@en
Structure of the catalytic fra ...... ly important catalytic residue
@nl
P2093
P2860
P3181
P356
P1476
Structure of the catalytic fra ...... ly important catalytic residue
@en
P2093
Gregers R Andersen
Sarah S Mohammad
Thomas Boesen
P2860
P304
P3181
P356
10.1074/JBC.M311055200
P407
P577
2004-03-12T00:00:00Z