Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase
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Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthaseStructure-Based Design and Synthesis of N ω -Nitro- l -Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural WaterMinimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsAnchored plasticity opens doors for selective inhibitor design in nitric oxide synthaseCrystal Structures of Constitutive Nitric Oxide Synthases in Complex with De Novo Designed Inhibitors †Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal ModelStructure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthasePotent, Highly Selective, and Orally Bioavailable Gem -Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide SynthaseExploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine DerivativesStructure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide SynthaseChiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitorsSelective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics SimulationsNitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform SelectivityThe Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide SynthasesElectrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide SynthaseDevelopment of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.Structure-based design of bacterial nitric oxide synthase inhibitors.Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.Acid-Facilitated Debenzylation of N-Boc, N-Benzyl Double Protected 2-Aminopyridinomethylpyrrolidine DerivativesHydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitorsPhenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitorsInhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.Role of nitric oxide synthase in insect cell radioresistance: an in-silico analysis.Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsyDiscovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases.Nitric oxide synthase inhibitors: a review of patents from 2011 to the present.Nitric oxide synthase and structure-based inhibitor design.Quinazolinones, Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation.A novel neuroprotective agent with antioxidant and nitric oxide synthase inhibitory action.Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin.Structures of human constitutive nitric oxide synthases.Structural basis for isoform-selective inhibition in nitric oxide synthase.Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.Re and (99m)Tc organometallic complexes containing pendant l-arginine derivatives as potential probes of inducible nitric oxide synthase.Role of the Nitrergic System of the Cuneiform Nucleus in Cardiovascular Responses in Urethane-Anesthetized Male Rats.Arginine thioacid in synthesis of arginine conjugates and peptides
P2860
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P2860
Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@ast
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@en
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@nl
type
label
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@ast
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@en
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@nl
prefLabel
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@ast
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@en
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@nl
P2093
P2860
P356
P1476
Structural basis for dipeptide ...... neuronal nitric oxide synthase
@en
P2093
Elizabeth A Litzinger
Huiying Li
José Antonio Gómez-Vidal
Joumana Jamal
Jung-Mi Hah
Mack L Flinspach
Richard B Silverman
Thomas L Poulos
Weiping Yang
P2860
P2888
P356
10.1038/NSMB704
P577
2004-01-01T00:00:00Z
P5875
P6179
1017543220