GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels
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Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiologyChemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell DeathGlcNAcstatins are nanomolar inhibitors of human O -GlcNAcase inducing cellular hyper- O -GlcNAcylationScreening-based discovery of drug-likeO-GlcNAcase inhibitor scaffoldsSubstrate and product analogues as human O-GlcNAc transferase inhibitorsInhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analysesCell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal HexosaminidasesSynergy of Peptide and Sugar in O-GlcNAcase Substrate RecognitionStructure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domainA crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologsModulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesO-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stressThe role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy.Quantitative secretome and glycome of primary human adipocytes during insulin resistance.O-GlcNAc cycling: emerging roles in development and epigenetics.O-GlcNAc signaling in the cardiovascular system.Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors.O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension.A little sugar goes a long way: the cell biology of O-GlcNAc.Chemical approaches to understanding O-GlcNAc glycosylation in the brain.Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease.The roles of O-linked β-N-acetylglucosamine in cardiovascular physiology and disease.O-Linked β-N-acetylglucosamine (O-GlcNAc) Acts as a Glucose Sensor to Epigenetically Regulate the Insulin Gene in Pancreatic Beta Cells.Chemical approaches to study O-GlcNAcylation.Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila.Glycan antagonists and inhibitors: a fount for drug discovery.Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system.Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis.The chemical neurobiology of carbohydratesTAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer.O-GlcNAc cycling: implications for neurodegenerative disorders.O-GlcNAc and the cardiovascular system.Glycosidase inhibition: assessing mimicry of the transition state.Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function.Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology.Chemical tools to probe cellular O-GlcNAc signalling.The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene ExpressionA selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes.The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System.
P2860
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P2860
GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels
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2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2006年の論文
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GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@ast
GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@en
GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@nl
type
label
GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@ast
GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@en
GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@nl
prefLabel
GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@ast
GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@en
GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@nl
P2093
P356
P1476
GlcNAcstatin: a picomolar, sel ...... ellular O-glcNAcylation levels
@en
P2093
Marianne Schimpl
Natalia A Shpiro
Sharon M Shepherd
Vladimir S Borodkin
P304
16484-16485
P356
10.1021/JA066743N
P407
P577
2006-12-01T00:00:00Z