Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis
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The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and AutoimmunityThe Second Enzyme in Pyrrolnitrin Biosynthetic Pathway Is Related to the Heme-Dependent Dioxygenase Superfamily †Structural and functional analyses of human tryptophan 2,3-dioxygenaseMolecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenaseStructural Study of a Flexible Active Site Loop in Human Indoleamine 2,3-Dioxygenase and Its Functional Implications.Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.EPR and Mössbauer spectroscopy show inequivalent hemes in tryptophan dioxygenase.Structure and reaction mechanism in the heme dioxygenases.Tryptophan-catabolizing enzymes - party of threeHeme enzyme structure and function.Exploring the mechanism of tryptophan 2,3-dioxygenaseEvidence for a ferryl intermediate in a heme-based dioxygenase.Enzyme reactivation by hydrogen peroxide in heme-based tryptophan dioxygenaseMolecular basis for the substrate stereoselectivity in tryptophan dioxygenase.Complete reaction mechanism of indoleamine 2,3-dioxygenase as revealed by QM/MM simulations.Human indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide.3D-Fun: predicting enzyme function from structureTryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis.Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase.Tryptophan oxygenation: mechanistic considerations.Mechanisms of tumor-induced T cell immune suppression and therapeutics to counter those effects.Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy.Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Heme-containing enzymes and inhibitors for tryptophan metabolism.Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase.Substrate stereo-specificity in tryptophan dioxygenase and indoleamine 2,3-dioxygenase.Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer.Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases.The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studiesA short history of heme dioxygenases: rise, fall and rise again.Substrate-protein interaction in human tryptophan dioxygenase: the critical role of H76.Probing the ternary complexes of indoleamine and tryptophan 2,3-dioxygenases by cryoreduction EPR and ENDOR spectroscopyBeta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics.Different Mechanisms of Catalytic Complex Formation in Two L-Tryptophan Processing Dioxygenases.High l-Trp affinity of indoleamine 2,3-dioxygenase 1 is attributed to two residues located in the distal heme pocket.
P2860
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P2860
Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis
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2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
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2007年の論文
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2007年学术文章
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2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
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name
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@ast
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@en
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@nl
type
label
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@ast
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@en
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@nl
prefLabel
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@ast
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@en
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@nl
P2093
P3181
P356
P1433
P1476
Crystal structure and mechanis ...... nd in quinolinate biosynthesis
@en
P2093
Brian R Crane
Seong A Kang
Shridhar Bale
Tadhg P Begley
Tathagata Mukherjee
Yang Zhang
P304
P3181
P356
10.1021/BI0620095
P407
P577
2007-01-09T00:00:00Z