Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase. Investigations of the putative catalytic glutamate-arginine pair and of residues responsible for substrate specificity
about
Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analoguesPost-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and releaseStructural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinaseBiological phosphorylation of an Unnatural Base Pair (UBP) using a Drosophila melanogaster deoxynucleoside kinase (DmdNK) mutant.Development of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues.Bacterial deoxyribonucleoside kinases are poor suicide genes in mammalian cells.
P2860
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P2860
Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase. Investigations of the putative catalytic glutamate-arginine pair and of residues responsible for substrate specificity
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Functional studies of active-s ...... ible for substrate specificity
@ast
Functional studies of active-s ...... ible for substrate specificity
@en
Functional studies of active-s ...... ible for substrate specificity
@nl
type
label
Functional studies of active-s ...... ible for substrate specificity
@ast
Functional studies of active-s ...... ible for substrate specificity
@en
Functional studies of active-s ...... ible for substrate specificity
@nl
prefLabel
Functional studies of active-s ...... ible for substrate specificity
@ast
Functional studies of active-s ...... ible for substrate specificity
@en
Functional studies of active-s ...... ible for substrate specificity
@nl
P2093
P2860
P1433
P1476
Functional studies of active-s ...... ible for substrate specificity
@en
P2093
Birgitte Munch-Petersen
Hans Eklund
Louise Egeblad-Welin
Yonathan Sonntag
P2860
P304
P356
10.1111/J.1742-4658.2007.05701.X
P407
P577
2007-03-01T00:00:00Z