Structural and Functional Consequences of Coenzyme Binding to the Inactive Asian Variant of Mitochondrial Aldehyde Dehydrogenase: ROLES OF RESIDUES 475 AND 487 - Wikidata - wikimedia - TriplyDB

Structural and Functional Consequences of Coenzyme Binding to the Inactive Asian Variant of Mitochondrial Aldehyde Dehydrogenase: ROLES OF RESIDUES 475 AND 487

Structural and Functional Consequences of Coenzyme Binding to the Inactive Asian Variant of Mitochondrial Aldehyde Dehydrogenase: ROLES OF RESIDUES 475 AND 487

http://www.wikidata.org/entity/Q27643918

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The three-dimensional structural basis of type II hyperprolinemia Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant Conserved Catalytic Residues of the ALDH1L1 Aldehyde Dehydrogenase Domain Control Binding and Discharging of the Coenzyme Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application Catalytic contribution of threonine 244 in human ALDH2 Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity.Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes: randomised crossover trial.Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus.Differential metabolism of organic nitrates by aldehyde dehydrogenase 1a1 and 2: substrate selectivity, enzyme inactivation, and active cysteine sites.A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations.Association between Carotid Intima-media Thickness and Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Chinese Han with Essential Hypertension The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.Roles of defective ALDH2 polymorphism on liver protection and cancer development.Associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms, lifestyles and hypertension risk in Chinese Han people Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1.Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2.Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde--in vitro studies and computational modeling.Dominance of the inactive Asian variant over activity and protein contents of mitochondrial aldehyde dehydrogenase 2 in human liver.Bioactivation of nitroglycerin by the East Asian variant of aldehyde dehydrogenase-2.Ethanol reduces lifespan, body weight, and serum alanine aminotransferase level of aldehyde dehydrogenase 2 knockout mouse.Alda-1 modulates the kinetic properties of mitochondrial aldehyde dehydrogenase (ALDH2).

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P2860

Structural and Functional Consequences of Coenzyme Binding to the Inactive Asian Variant of Mitochondrial Aldehyde Dehydrogenase: ROLES OF RESIDUES 475 AND 487

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2007 nî lūn-bûn

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Structural and Functional Cons ...... ROLES OF RESIDUES 475 AND 487

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Structural and Functional Cons ...... ROLES OF RESIDUES 475 AND 487

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Heather N Larson

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Henry Weiner

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Jianzhong Zhou

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Jonathan S Stamler

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Thomas D Hurley

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Zhiqiang Chen

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P2860

An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase

Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion

Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

The finer things in X-ray diffraction data collection

The CCP4 suite: programs for protein crystallography

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