Structure-guided development of affinity probes for tyrosine kinases using chemical genetics - Wikidata - wikimedia - TriplyDB

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics

http://www.wikidata.org/entity/Q27643967

about

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1.6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases Chemical genetic strategy for targeting protein kinases based on covalent complementarity Structure-Guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase Technology Mechanism for activation of mutated epidermal growth factor receptors in lung cancer Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model.Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.Co-conserved features associated with cis regulation of ErbB tyrosine kinases.Strategies for discovering and derisking covalent, irreversible enzyme inhibitors.Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity.In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent.Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.Irreversible inhibitors of c-Src kinase that target a nonconserved cysteine.A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.New approaches for dissecting protease functions to improve probe development and drug discovery Cheminfomatic-based Drug Discovery of Human Tyrosine Kinase Inhibitors.A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases.Structure and clinical relevance of the epidermal growth factor receptor in human cancer Calcium-dependent signaling and kinases in apicomplexan parasites.Activity-based probes as a tool for functional proteomic analysis of proteases.Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases mTOR Mediated Anti-Cancer Drug Discovery.Activity-based probes: discovering new biology and new drug targets.Nanoparticles for cancer therapy using magnetic forces.Epidermal growth factor receptor inhibitors: a patent review (2010 - present).Studying the Conformation of a Receptor Tyrosine Kinase in Solution by Inhibitor-Based Spin Labeling.A general approach for the development of fluorogenic probes suitable for no-wash imaging of kinases in live cells.Ibrutinib (ImbruvicaTM) potently inhibits ErbB receptor phosphorylation and cell viability of ErbB2-positive breast cancer cells.Structure-functional prediction and analysis of cancer mutation effects in protein kinases.Targeting the off-targets: a computational bioinformatics approach to understanding the polypharmacology of nelfinavir.

P2860

Q24338526-B9E4F373-4CD4-4B21-834C-B516B1BF3E29 Q27349131-8F11BE33-DDA6-424A-A012-050D7727B083 Q27649889-53B27BB2-16F5-4AEB-838B-20907D4CA924 Q27671824-E580E4BB-D9CC-4728-9DCE-A62AB4EE5E80 Q27679025-D5F85DCB-71E7-40D3-92B6-DB952F5D34E3 Q27679902-45571891-355F-4985-89B3-761161A2799C Q27691330-A3E5D6FC-7033-4CAB-881B-B083B6E489EC Q28283214-B338EE69-523D-46DF-9A86-838B09579CA5 Q28306744-F34DEF57-641D-44F4-B708-3A44356DF7B5 Q28477930-5D213F7E-517A-4757-81E8-14AD8C869E25 Q29616828-753F1D0B-8586-4E00-86B9-5C17F38628CF Q30494625-E8146D16-45A7-4784-8FCE-D98D3C737564 Q33778237-C114C8F6-DDAC-44BB-899B-5817541EAF05 Q34023143-74A178AC-0E14-4635-9D13-B9525E02B035 Q34025360-0CF6F6C0-C6DF-43D6-BF15-80D39398AFB9 Q34067085-3390EEB9-84DE-49B9-9A33-C31461265756 Q34286645-0FE94EDA-B675-4327-835D-6D30926B07FB Q34976925-C870A83B-313F-4ACD-8F90-E4DB668435D6 Q35896406-B9518F56-A87A-431E-AB95-8EDCE78DC5E0 Q36368323-AB06340D-CC53-4992-88E5-0C5587E875BA Q36405755-2A504BBF-C731-4BCF-BAE9-0B4C9811FEA9 Q36408265-1C115E81-C6CE-4CFD-863A-7B4690E11FA9 Q36442058-FD7CDE58-3824-4B22-90FC-8C10D887AA5D Q36669662-812B6531-E7C4-4FD3-A7EC-1252D85C0E46 Q36677068-8845AEFE-F95B-4E55-9466-44E89FCE2004 Q37043596-DA0722D5-FB08-40B6-A1DD-DA4768C2FF95 Q37043619-158E26C8-6070-4F9B-B11C-AA55A242AFD0 Q37122918-3C7B568A-9CDA-44EB-9911-C8EEDEF48B38 Q37283662-0CB5C59F-C2F6-45E5-8D67-A4418E9EA3DE Q37304140-2481301D-ED4E-4235-9058-1962ACF9DA75 Q37687519-FE614EE9-5528-40E0-B7D5-5EF6A74FCE57 Q37771869-10D00FCC-2650-486B-9A12-5F7652E3BB81 Q37795611-47DCEA61-FC19-4476-B73C-D92697B3E982 Q37990023-970C5264-886C-48EB-ABCB-7EE0EEF0216A Q38175432-90349499-29DE-49C2-B94B-0621C1BB4362 Q38719332-CAB2E1D8-B53E-4F02-BDA5-511EB862907F Q38944958-3527C556-2EA4-4987-9BF7-BC9F556D820D Q38969795-A59990A7-392A-4DE3-8B4C-53402422D914 Q38987589-7588D581-30A6-489D-92C5-E480A20C7741 Q39204077-DE5FFDAA-FA3A-40A1-84F7-61E20752A345

P2860

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics

http://www.wikidata.org/entity/Q27643967

description

2007 nî lūn-bûn

@nan

2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Structure-guided development o ...... inases using chemical genetics

@ast

Structure-guided development o ...... inases using chemical genetics

@en

Structure-guided development o ...... inases using chemical genetics

@nl

type

label

Structure-guided development o ...... inases using chemical genetics

@ast

Structure-guided development o ...... inases using chemical genetics

@en

Structure-guided development o ...... inases using chemical genetics

@nl

prefLabel

Structure-guided development o ...... inases using chemical genetics

@ast

Structure-guided development o ...... inases using chemical genetics

@en

Structure-guided development o ...... inases using chemical genetics

@nl

P1433

Q27643967-F5C8C473-DCFE-4075-AEEA-AB01FA67D37E

P1476

Q27643967-C9909A4D-52C8-45AD-BB29-D60DEDF8C006

P2093

Q27643967-02936A96-A78D-4159-AEE4-A623C0E5A323

Q27643967-0D0FCD8A-2E83-4874-91E5-69898F9E7069

Q27643967-1DE52968-4226-4107-A8B6-7BB1C1A5EA0A

Q27643967-256E5111-CB91-4789-9604-7D408A060191

Q27643967-690BE2D4-67A5-4B42-A853-59C117A9CD50

Q27643967-A8C79AD2-35E0-44F7-9BD3-9B6274C114AC

Q27643967-BD29BEE3-CBBA-4150-B1D5-987FD5E6FB45

Q27643967-E9D23B0E-B970-4E1D-994A-57D49A6A7201

Q27643967-EB861427-083A-4960-8040-9C1197F0566E

Q27643967-EC0A8D30-B481-4319-BE89-BBC719441E93

P2888

Q27643967-CD3C2A17-378F-4554-86CD-7C4CD1093AF6

P304

Q27643967-2207B315-67B8-4556-A465-D00428C0A2D0

P31

Q27643967-CC078F76-9E49-4236-A007-136980585F59

P3181

Q27643967-D9DF769B-4A20-4F68-B102-7A6DB456BF0E

P356

Q27643967-CB4F1A57-89DE-40C7-A639-03788D2F27FE

P433

Q27643967-001B10DC-6D28-426F-B56B-4A09E975DE71

P478

Q27643967-51DB7964-1D0E-4835-8E82-0969C08CA138

P577

Q27643967-E6DA271B-E768-48CC-8E59-407EC85A2209

P5875

Q27643967-C8A5DDF2-6F59-4843-9C68-39F1C7929526

P6179

Q27643967-9DF007FD-4CFD-4766-9B01-CF9E8796EFCF

P698

Q27643967-A3EF923C-FE7A-4A76-9E39-2E996CAA17AA

P3181

P356

P1433

Nature Chemical Biology

P1476

Structure-guided development o ...... inases using chemical genetics

@en

P2093

Cai-Hong Yun

http://www.w3.org/2001/XMLSchema#string

Chao Zhang

http://www.w3.org/2001/XMLSchema#string

Charles Kung

http://www.w3.org/2001/XMLSchema#string

Daniel Rauh

http://www.w3.org/2001/XMLSchema#string

Haridas Rode

http://www.w3.org/2001/XMLSchema#string

Jimmy A Blair

http://www.w3.org/2001/XMLSchema#string

Kevan M Shokat

http://www.w3.org/2001/XMLSchema#string

Michael J Eck

http://www.w3.org/2001/XMLSchema#string

Qi-Wen Fan

http://www.w3.org/2001/XMLSchema#string

William A Weiss

http://www.w3.org/2001/XMLSchema#string

P2888

P304

229-38

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

3334887

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/NCHEMBIO866

http://www.w3.org/2001/XMLSchema#string

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

3

http://www.w3.org/2001/XMLSchema#string

P577

2007-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6473129

http://www.w3.org/2001/XMLSchema#string

P6179

1048722714

http://www.w3.org/2001/XMLSchema#string

P698

17334377

http://www.w3.org/2001/XMLSchema#string