Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors
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Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)A spatial simulation approach to account for protein structure when identifying non-random somatic mutationsBRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition.Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance.PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation.Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3βGlobal connectivity of hub residues in Oncoprotein structures encodes genetic factors dictating personalized drug response to targeted Cancer therapy.Discovery and pharmacophore studies of novel pyrazole-based anti-melanoma agents.
P2860
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P2860
Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@ast
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@en
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@nl
type
label
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@ast
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@en
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@nl
prefLabel
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@ast
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@en
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@nl
P2093
P356
P1476
Design and optimization of pot ...... ydronaphthalene Raf inhibitors
@en
P2093
Alexandra E Gould
Bheemashankar Kulkarni
Cheryl Farrer
Christelle C Renou
Christopher Blackburn
Dave Janowick
Dong Mei Zhang
Dylan B England
Emily F Calderwood
Erin Paske
P304
P356
10.1021/JM101479Y
P407
P577
2011-03-24T00:00:00Z