Evolved to be active: sulfate ions define substrate recognition sites of CK2alpha and emphasise its exceptional role within the CMGC family of eukaryotic protein kinases
about
The interaction of CK2α and CK2β, the subunits of protein kinase CK2, requires CK2β in a preformed conformation and is enthalpically drivenQuinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2RETRACTED: Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by AutophosphorylationA detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinaseEnzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α'Crystal structure of human CK2α at 1.06 Å resolutionStructural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140A subnanomolar fluorescent probe for protein kinase CK2 interaction studiesThe multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2α indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathwayCo-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tailIndividualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics.Antitumoral activity of allosteric inhibitors of protein kinase CK2.Identification of a novel potent, selective and cell permeable inhibitor of protein kinase CK2 from the NIH/NCI Diversity Set Library.Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.Conformational flexibility of human casein kinase catalytic subunit explored by metadynamics.Selective knockout of the casein kinase 2 in d1 medium spiny neurons controls dopaminergic function.The role of the N-terminal domain in the regulation of the "constitutively active" conformation of protein kinase CK2α: insight from a molecular dynamics investigation.Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'.A novel allosteric site in casein kinase 2α discovered using combining bioinformatics and biochemistry methods.A π-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors.Evidence for aggregation of protein kinase CK2 in the cell: a novel strategy for studying CK2 holoenzyme interaction by BRET(2).The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition.
P2860
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P2860
Evolved to be active: sulfate ions define substrate recognition sites of CK2alpha and emphasise its exceptional role within the CMGC family of eukaryotic protein kinases
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@ast
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@en
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@nl
type
label
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@ast
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@en
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@nl
prefLabel
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@ast
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@en
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@nl
P1476
Evolved to be active: sulfate ...... of eukaryotic protein kinases
@en
P2093
Christina W Yde
Inessa Ermakova
P304
P356
10.1016/J.JMB.2007.04.068
P407
P577
2007-07-13T00:00:00Z