Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism - Wikidata - wikimedia - TriplyDB

Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism

Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism

http://www.wikidata.org/entity/Q27645400

about

Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop Characterization of a novel small molecule subtype specific estrogen-related receptor alpha antagonist in MCF-7 breast cancer cells Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor.Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1 A novel steroidal inhibitor of estrogen-related receptor alpha (ERR alpha).The NR3B subgroup: an ovERRview The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression.ERRalpha: a metabolic function for the oldest orphan.Pharmacological approaches to restore mitochondrial function.The orphan nuclear receptors at their 25-year reunion.Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor.Modulation of estrogen related receptor alpha activity by the kinesin KIF17.On the intractability of estrogen-related receptor alpha as a target for activation by small molecules.ERRα protein is stabilized by LSD1 in a demethylation-independent manner.Divergent regulation of the Osteopontin promoter by the estrogen receptor-related receptors is isoform- and cell context dependent.A structural biology view of target drugability.

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P2860

Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism

http://www.wikidata.org/entity/Q27645400

description

2007 nî lūn-bûn

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2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի օգոստոսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Crystal structure of human est ...... its novel molecular mechanism

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Crystal structure of human est ...... its novel molecular mechanism

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Crystal structure of human est ...... its novel molecular mechanism

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Crystal structure of human est ...... its novel molecular mechanism

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Crystal structure of human est ...... its novel molecular mechanism

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Crystal structure of human est ...... its novel molecular mechanism

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Crystal structure of human est ...... its novel molecular mechanism

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Crystal structure of human est ...... its novel molecular mechanism

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Crystal structure of human est ...... its novel molecular mechanism

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Journal of Biological Chemistry

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Crystal structure of human est ...... its novel molecular mechanism

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P2093

Andre Strauss

http://www.w3.org/2001/XMLSchema#string

Anke Blechschmidt

http://www.w3.org/2001/XMLSchema#string

Brigitte Fournier

http://www.w3.org/2001/XMLSchema#string

Jean-Marc Schlaeppi

http://www.w3.org/2001/XMLSchema#string

Joerg Kallen

http://www.w3.org/2001/XMLSchema#string

Johannes Ottl

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Marcel J J Blommers

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Martin Geiser

http://www.w3.org/2001/XMLSchema#string

Rene Beerli

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Rene Lattmann

http://www.w3.org/2001/XMLSchema#string

P2860

Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha

Improved methods for building protein models in electron density maps and the location of errors in these models

PROCHECK: a program to check the stereochemical quality of protein structures

Processing of X-ray diffraction data collected in oscillation mode

Structural insights into the mode of action of a pure antiestrogen

Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

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23231-9

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scholarly article

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10.1074/JBC.M703337200

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32

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282

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2007-08-10T00:00:00Z

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crystal structure