Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism
about
Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loopCharacterization of a novel small molecule subtype specific estrogen-related receptor alpha antagonist in MCF-7 breast cancer cellsNovel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancerImportance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor.Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1A novel steroidal inhibitor of estrogen-related receptor alpha (ERR alpha).The NR3B subgroup: an ovERRviewThe asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanismMutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression.ERRalpha: a metabolic function for the oldest orphan.Pharmacological approaches to restore mitochondrial function.The orphan nuclear receptors at their 25-year reunion.Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor.Modulation of estrogen related receptor alpha activity by the kinesin KIF17.On the intractability of estrogen-related receptor alpha as a target for activation by small molecules.ERRα protein is stabilized by LSD1 in a demethylation-independent manner.Divergent regulation of the Osteopontin promoter by the estrogen receptor-related receptors is isoform- and cell context dependent.A structural biology view of target drugability.
P2860
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P2860
Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Crystal structure of human est ...... its novel molecular mechanism
@ast
Crystal structure of human est ...... its novel molecular mechanism
@en
Crystal structure of human est ...... its novel molecular mechanism
@nl
type
label
Crystal structure of human est ...... its novel molecular mechanism
@ast
Crystal structure of human est ...... its novel molecular mechanism
@en
Crystal structure of human est ...... its novel molecular mechanism
@nl
prefLabel
Crystal structure of human est ...... its novel molecular mechanism
@ast
Crystal structure of human est ...... its novel molecular mechanism
@en
Crystal structure of human est ...... its novel molecular mechanism
@nl
P2093
P2860
P356
P1476
Crystal structure of human est ...... its novel molecular mechanism
@en
P2093
Andre Strauss
Anke Blechschmidt
Brigitte Fournier
Jean-Marc Schlaeppi
Joerg Kallen
Johannes Ottl
Marcel J J Blommers
Martin Geiser
Rene Beerli
Rene Lattmann
P2860
P304
P356
10.1074/JBC.M703337200
P407
P577
2007-08-10T00:00:00Z