The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
about
Conformational coupling across the plasma membrane in activation of the EGF receptorCell signaling by receptor tyrosine kinasesErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylationAdaptive resistance to targeted therapies in cancerStructure-function relationships of ErbB RTKs in the plasma membrane of living cellsDesign principles underpinning the regulatory diversity of protein kinasesEnhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancerInhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR SignalingCoarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylationSingle Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated PitsStructural analysis of the catalytically inactive kinase domain of the human EGF receptor 3Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF ReceptorErbB polymorphisms: insights and implications for response to targeted cancer therapeuticsCrucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2Overexpression of CARMA3 in non-small-cell lung cancer is linked for tumor progressionA potential peptide therapeutic derived from the juxtamembrane domain of the epidermal growth factor receptorMitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant TransformationCharacterization of membrane protein interactions in plasma membrane derived vesicles with quantitative imaging Förster resonance energy transferStructure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesLineage-specific co-evolution of the Egf receptor/ligand signaling system.A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregationHer4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro systemConformational changes in receptor tyrosine kinase signaling: an ErbB garden of delightsSynthesis and biochemical characterization of EGF receptor in a water-soluble membrane model systemCo-conserved features associated with cis regulation of ErbB tyrosine kinases.Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer.Mechanisms of activation of receptor tyrosine kinases: monomers or dimers.Phosphorylation-dependent differential regulation of plant growth, cell death, and innate immunity by the regulatory receptor-like kinase BAK1.Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerizationAsp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.Human epidermal growth factor receptor (HER1) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry.Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy.Convergence between Wnt-β-catenin and EGFR signaling in cancer.Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells.Plakophilin-2 promotes activation of epidermal growth factor receptor.Kinase-mediated quasi-dimers of EGFRAllosteric communication across the native and mutated KIT receptor tyrosine kinase.
P2860
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P2860
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@ast
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@en
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@nl
type
label
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@ast
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@en
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@nl
prefLabel
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@ast
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@en
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@nl
P2093
P2860
P3181
P1433
P1476
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
@en
P2093
Ambra Pozzi
Diego Alvarado
Graham Carpenter
Katarina Moravcevic
Monica Red Brewer
Sung Hee Choi
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2009.04.034
P577
2009-06-26T00:00:00Z