Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center - Wikidata - wikimedia - TriplyDB

Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center

Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center

http://www.wikidata.org/entity/Q27646520

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Recent progress in structure-based anti-influenza drug design Computable features required to evaluate the efficacy of drugs and a universal algorithm to find optimally effective drug in a drug complex Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity High-Resolution Structure of the N-Terminal Endonuclease Domain of the Lassa Virus L Polymerase in Complex with Magnesium Ions Structural Basis for the Identification of the N-Terminal Domain of Coronavirus Nucleocapsid Protein as an Antiviral Target Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1 The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease Anti-influenza activity of c60 fullerene derivatives.Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay.Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014.Emerging antiviral resistant strains of influenza A and the potential therapeutic targets within the viral ribonucleoprotein (vRNP) complex.New prospects for the rational design of antivirals.Tracking the Evolution in Phylogeny, Structure and Function of H5N1 Influenza Virus PA Gene.Sequence, structure and functional diversity of PD-(D/E)XK phosphodiesterase superfamily The nuclease domain of the SPP1 packaging motor coordinates DNA cleavage and encapsidation.A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins.New Insight into Metal Ion-Driven Catalysis of Nucleic Acids by Influenza PA-Nter N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes.Crucial role of PA in virus life cycle and host adaptation of influenza A virus.Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease.Binding mode prediction and inhibitor design of anti-influenza virus diketo acids targeting metalloenzyme RNA polymerase by molecular docking Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage.Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit.Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain.

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P2860

Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center

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2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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Cong Zhao

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Liang Zhang

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Ming Ma

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Shuaiyi Liang

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Xuemei Li

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Yingfang Liu

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Yu Guo

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Yutao Chen

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Zhiyong Lou

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Zihe Rao

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P2860

The structural basis for cap binding by influenza virus polymerase subunit PB2

Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Recognition of flanking DNA sequences by EcoRV endonuclease involves alternative patterns of water-mediated contacts

Phasercrystallographic software

Refinement of macromolecular structures by the maximum-likelihood method

PHENIX: building new software for automated crystallographic structure determination

The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits

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824031

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10.1128/JVI.00911-09

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18

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83

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19587036

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2738217

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