A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
about
MET: a critical player in tumorigenesis and therapeutic targetMolecular recognition of parathyroid hormone by its G protein-coupled receptorStructural basis for agonism and antagonism of hepatocyte growth factorEngineered variants of InlB with an additional leucine-rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complexThe solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type foldNoncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor.Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapyEngineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists.Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cellsA role for septins in the interaction between the Listeria monocytogenes INVASION PROTEIN InlB and the Met receptorBiochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621Flexibility and small pockets at protein-protein interfaces: New insights into druggability.Targeting the HGF-cMET Axis in Hepatocellular Carcinoma.Current Screens Based on the AlphaScreen Technology for Deciphering Cell Signalling PathwaysPseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer.Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns.Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor.Allosteric peptide activators of pro-hepatocyte growth factor stimulate Met signaling.Analogs of the hepatocyte growth factor and macrophage-stimulating protein hinge regions act as Met and Ron dual inhibitors in pancreatic cancer cells.An engineered dimeric fragment of hepatocyte growth factor is a potent c-MET agonist.Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.Physiological Signaling and Structure of the HGF Receptor MET.
P2860
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P2860
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@ast
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@en
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@nl
type
label
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@ast
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@en
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@nl
prefLabel
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@ast
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@en
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@nl
P2093
P2860
P921
P356
P1476
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
@en
P2093
ChongFeng Gao
Cindy Miranti
Ermanno Gherardi
George Vande Woude
Jennifer Daugherty
W David Tolbert
P2860
P304
P356
10.1073/PNAS.0704290104
P407
P577
2007-09-11T00:00:00Z