Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist
about
TNF biology, pathogenic mechanisms and emerging therapeutic strategiesSubversion of cytokine networks by virally encoded decoy receptorsThe protective antibodies induced by a novel epitope of human TNF-alpha could suppress the development of collagen-induced arthritis.A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model.Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy.TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion.Antibody-mediated inhibition of TNFR1 attenuates disease in a mouse model of multiple sclerosis.Thermodynamics-based drug design: strategies for inhibiting protein-protein interactions.Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension.The design and characterization of receptor-selective APRIL variantsIn vivo maturation of allo-specific CD8 CTL and prevention of lupus-like graft-versus-host disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor.Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex.Development of novel drug delivery systems using phage display technology for clinical application of protein drugsAntagonists of TNF action: clinical experience and new developments.A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification.Expression and purification of a natural N-terminal pre-ligand assembly domain of tumor necrosis factor receptor 1 (TNFR1 PLAD) and preliminary activity determination.ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibodyUnraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors.Creation of mouse TNFR2-selective agonistic TNF mutants using a phage display technique.Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis.Structural modeling of tumor necrosis factor: A protein of immunological importance.Role of TNF-TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications.
P2860
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P2860
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@ast
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@en
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@nl
type
label
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@ast
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@en
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@nl
prefLabel
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@ast
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@en
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@nl
P2093
P2860
P50
P356
P1476
Creation and X-ray structure a ...... crosis factor-alpha antagonist
@en
P2093
Akiko Ohkawa
Akira Yamamoto
Bharat B Aggarwal
Hiroko Shibata
Hiromi Nabeshi
Hiroyuki Kayamuro
Kazuya Nagano
Kyoko Minowa
Madoka Taniai
Shinsaku Nakagawa
P2860
P304
P356
10.1074/JBC.M707933200
P407
P577
2007-11-14T00:00:00Z