ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes
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Geometric attributes of retaining glycosyltransferase enzymes favor an orthogonal mechanismCrossroads between Bacterial and Mammalian GlycosyltransferasesStructural and mechanistic basis for a new mode of glycosyltransferase inhibitionCysteine-to-Serine Mutants Dramatically Reorder the Active Site of Human ABO(H) Blood Group B Glycosyltransferase without Affecting Activity: Structural Insights into Cooperative Substrate BindingStructure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigenSequence-dependent effects of cryoprotectants on the active sites of the human ABO(H) blood group A and B glycosyltransferasesBase-modified Donor Analogues Reveal Novel Dynamic Features of a GlycosyltransferaseMechanistic Insights into the Retaining Glucosyl-3-phosphoglycerate Synthase from MycobacteriaStructures of Complexes of a Metal-independent Glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-Acetylgalactosamine (UDP-GalNAc) and Its Hydrolysis ProductsStructures of a human blood group glycosyltransferase in complex with a photo-activatable UDP-Gal derivative reveal two different binding conformationsDesign of glycosyltransferase inhibitors: pyridine as a pyrophosphate surrogateA Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining GlycosyltransferaseStructure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin ResistanceA glycosyltransferase inhibitor from a molecular fragment library simultaneously interferes with metal ion and substrate binding.Preliminary joint neutron time-of-flight and X-ray crystallographic study of human ABO(H) blood group A glycosyltransferase.Bioconjugation and detection of lactosamine moiety using alpha1,3-galactosyltransferase mutants that transfer C2-modified galactose with a chemical handle.Novel UDP-GalNAc Derivative Structures Provide Insight into the Donor Specificity of Human Blood Group Glycosyltransferase.Family 6 glycosyltransferases in vertebrates and bacteria: inactivation and horizontal gene transfer may enhance mutualism between vertebrates and bacteria.High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.Flexibility and mutagenic resiliency of glycosyltransferases.A new concept for glycosyltransferase inhibitors: nonionic mimics of the nucleotide donor of the human blood group B galactosyltransferase.High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise MannerThermodynamic signature of substrates and substrate analogs binding to human blood group B galactosyltransferase from isothermal titration calorimetry experiments.Protein NMR Studies of Substrate Binding to Human Blood Group A and B Glycosyltransferases.Identification of a novel missense mutation (563G>a) in the ABO gene associated with a Bel phenotype.Glycosyltransfer in mutants of putative catalytic residue Glu303 of the human ABO(H) A and B blood group glycosyltransferases GTA and GTB proceeds through a labile active site.
P2860
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P2860
ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
ABO(H) blood group A and B gly ...... pecific conformational changes
@ast
ABO(H) blood group A and B gly ...... pecific conformational changes
@en
ABO(H) blood group A and B gly ...... pecific conformational changes
@nl
type
label
ABO(H) blood group A and B gly ...... pecific conformational changes
@ast
ABO(H) blood group A and B gly ...... pecific conformational changes
@en
ABO(H) blood group A and B gly ...... pecific conformational changes
@nl
prefLabel
ABO(H) blood group A and B gly ...... pecific conformational changes
@ast
ABO(H) blood group A and B gly ...... pecific conformational changes
@en
ABO(H) blood group A and B gly ...... pecific conformational changes
@nl
P2093
P2860
P50
P356
P1476
ABO(H) blood group A and B gly ...... pecific conformational changes
@en
P2093
Javier A Alfaro
Mattias Persson
Monica M Palcic
Nina O L Seto
Robert Polakowski
Ruixiang Blake Zheng
Svetlana N Borisova
P2860
P304
P356
10.1074/JBC.M708669200
P407
P577
2008-04-11T00:00:00Z