T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties
about
Review of the Structural and Dynamic Mechanisms of PPARγ Partial AgonismUnacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice.Pharmacophore-driven identification of PPARγ agonists from natural sources.In Silico Identification of Potent PPAR-γ Agonists from Traditional Chinese Medicine: A Bioactivity Prediction, Virtual Screening, and Molecular Dynamics Study.Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions.Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis.Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice.Three-in-one agonists for PPAR-α, PPAR-γ, and PPAR-δ from traditional Chinese medicine.Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis.Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands.Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex.PPARgamma and its ligands: therapeutic implications in cardiovascular disease.LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.Discovery and development of selective PPAR gamma modulators as safe and effective antidiabetic agents.Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor.Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy.An alternate binding site for PPARγ ligandsChiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγ.Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs.Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced ThermogenesisSAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated ReceptorγActivators: A Perspective
P2860
Q26782232-6439E4C8-0838-4A3A-9CC8-F5BA400622ECQ33644530-D41F4B97-6A4D-4B41-BB84-DBAE6EBFFAF8Q33744181-F2E9FF10-0D54-4D74-9BAF-885B7C4833FBQ33757779-DDA40BAF-E137-48BF-89B4-64160B44E772Q33782620-B69CBD94-A926-4EAD-80A1-921D2F946656Q33916179-4B9306BE-B91A-4CA9-9F71-8016CE8593EDQ33976093-E4762D38-7938-41C7-9357-BE03854AF113Q34316470-454D6DFB-59EF-4E56-B8F1-9BAAD5E93DCEQ35237706-849006A4-798B-4385-90A4-D8F53654EDB9Q35395528-16B26E76-8D7D-4A8D-AE71-7DB1E1F18A4DQ36517153-D6869421-CF4A-4915-A4BD-1C3104468496Q37179467-5E75BA23-C31D-4E63-835B-7ACF862E36B4Q37622614-A24A3EB3-FD1C-4874-84CC-6E177545A655Q37724195-ACB58420-98CC-41FB-9A5A-BBC0EC4BB60BQ38433439-E0F0910D-4942-41A7-9B7C-DDF4C3AC2523Q38435324-7EF9E87F-BDFD-4CC7-B511-83992233F427Q38449883-AF3FADAD-CBA8-4A17-88B2-CCC8A2CA8D94Q47130302-DA6A4644-DB4F-42F8-9267-EEC91D789987Q47169300-19ECA2E5-9F09-436F-8FE4-EED94DAE60DEQ58703696-2B5A5BE2-285C-4A3E-9C07-0DA6C4ABB2BBQ58919671-09C83551-CCD3-461B-98C9-58E640EB0F2E
P2860
T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@ast
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@en
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@nl
type
label
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@ast
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@en
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@nl
prefLabel
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@ast
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@en
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@nl
P2093
P2860
P356
P1476
T2384, a novel antidiabetic ag ...... eptor gamma binding properties
@en
P2093
Jennifer Weiszmann
Jin-Long Chen
Jinsong Liu
Michelle Lindstrom
Nigel Walker
Noboru Furukawa
Olga Plotnikova
Patrick Escaron
P2860
P304
P356
10.1074/JBC.M800104200
P407
P577
2008-04-04T00:00:00Z