Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation
about
NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domainNF-κB regulation: lessons from structuresCrystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitinCrystal structure of inhibitor of κB kinase βSolution Structure of an Archaeal DNA Binding Protein with an Eukaryotic Zinc Finger FoldBinding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-κB Essential Modulator).The unusual UBZ domain of Saccharomyces cerevisiae polymerase ηCovalent modification of the NF-κB essential modulator (NEMO) by a chemical compound can regulate its ubiquitin binding properties in vitro.Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology modelThe IκB kinase complex in NF-κB regulation and beyond.Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity.Structural basis for ubiquitin recognition by ubiquitin-binding zinc finger of FAAP20.New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein.Importance of long-time simulations for rare event sampling in zinc finger proteinsMolecular basis of NF-κB signalingNEMO oligomerization and its ubiquitin-binding properties.Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity.The zinc finger domain of IKKγ (NEMO) protein in health and diseaseA structural guide to proteins of the NF-kappaB signaling module.Noncanonical NF-κB signaling is limited by classical NF-κB activity.Structural studies of NF-κB signaling.Rare mendelian primary immunodeficiency diseases associated with impaired NF-κB signalingDisulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).The zinc finger of NEMO is a functional ubiquitin-binding domain.Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG / NEMO mutations.Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.Two-sided ubiquitin binding of NF-κB essential modulator (NEMO) zinc finger unveiled by a mutation associated with anhidrotic ectodermal dysplasia with immunodeficiency syndrome.Uncovering Large-Scale Conformational Change in Molecular Dynamics without Prior Knowledge.Visualizing correlated motion with HDBSCAN clustering.All-atom molecular dynamics comparison of disease-associated zinc fingers.
P2860
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P2860
Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Solution structure of NEMO zin ...... iciency-related point mutation
@ast
Solution structure of NEMO zin ...... iciency-related point mutation
@en
Solution structure of NEMO zin ...... iciency-related point mutation
@nl
type
label
Solution structure of NEMO zin ...... iciency-related point mutation
@ast
Solution structure of NEMO zin ...... iciency-related point mutation
@en
Solution structure of NEMO zin ...... iciency-related point mutation
@nl
prefLabel
Solution structure of NEMO zin ...... iciency-related point mutation
@ast
Solution structure of NEMO zin ...... iciency-related point mutation
@en
Solution structure of NEMO zin ...... iciency-related point mutation
@nl
P2093
P1476
Solution structure of NEMO zin ...... iciency-related point mutation
@en
P2093
Emilie Vinolo
Fabrice Agou
Florence Cordier
Michel Véron
P304
P356
10.1016/J.JMB.2008.01.048
P407
P577
2008-04-11T00:00:00Z