Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities - Wikidata - wikimedia - TriplyDB

Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities

Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities

http://www.wikidata.org/entity/Q27650138

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A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains Mechanisms of granulin deficiency: lessons from cellular and animal models The Evolution of the Secreted Regulatory Protein Progranulin Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells.miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease GP88 (progranulin): a novel tissue and circulating biomarker for non-small cell lung carcinoma.Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.Suppression of Ov-grn-1 encoding granulin of Opisthorchis viverrini inhibits proliferation of biliary epithelial cells.rs5848 polymorphism and serum progranulin level The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.Progranulin: a promising therapeutic target for rheumatoid arthritis.Low plasma progranulin levels in children with autism.Progranulin: a growth factor, a novel TNFR ligand and a drug target Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes.Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors.Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept.Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Clinical relevance of adipokines.Progranulin (GP88) tumor tissue expression is associated with increased risk of recurrence in breast cancer patients diagnosed with estrogen receptor positive invasive ductal carcinoma.Missense mutations in progranulin gene associated with frontotemporal lobar degeneration: study of pathogenetic features Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance.Fully reduced granulin-B is intrinsically disordered and displays concentration-dependent dynamics Signaling Pathway of GP88 (Progranulin) in Breast Cancer Cells: Upregulation and Phosphorylation of c-myc by GP88/Progranulin in Her2-Overexpressing Breast Cancer Cells Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue.Determination of GP88 (progranulin) expression in breast tumor biopsies improves the risk predictive value of the Nottingham Prognostic Index.Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.EphA2 is a functional receptor for the growth factor progranulin.Growth factors as active participants in carcinogenesis: a perspective.Structure, function, and mechanism of progranulin; the brain and beyond.Recent insights into the involvement of progranulin in frontotemporal dementia.Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS.Progranulin, lysosomal regulation and neurodegenerative disease.Functional characterization and molecular mechanism exploration of three granulin epithelin precursor splice variants in biomineralization of the pearl oyster Pinctada fucata.Hypothetical granulin-like molecule from Fasciola hepatica identified by bioinformatics analysis.Progranulin stimulated by LPA promotes the migration of aggressive breast cancer cells.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.

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P2860

Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities

http://www.wikidata.org/entity/Q27650138

description

2008 nî lūn-bûn

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2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2008年の論文

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Structure dissection of human ...... h unique functional activities

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Structure dissection of human ...... h unique functional activities

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Protein Science

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Structure dissection of human ...... h unique functional activities

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Andrew Bateman

http://www.w3.org/2001/XMLSchema#string

Anna Vinogradova

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Dmitri Tolkatchev

http://www.w3.org/2001/XMLSchema#string

Feng Ni

http://www.w3.org/2001/XMLSchema#string

Hugh P J Bennett

http://www.w3.org/2001/XMLSchema#string

Ping Wang

http://www.w3.org/2001/XMLSchema#string

Ping Xu

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Suneil Malik

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Zhigang Chen

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P2860

Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains

Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor)

Characterisation of UGP and its relationship with beta-core fragment

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

A 30-residue fragment of the carp granulin-1 protein folds into a stack of two beta-hairpins similar to that found in the native protein

Design and solution structure of a well-folded stack of two beta-hairpins based on the amino-terminal fragment of human granulin A

A peptide derived from the C-terminal part of a plant cysteine protease folds into a stack of two beta-hairpins, a scaffold present in the emerging family of granulin-like growth factors

Solution structures of a 30-residue amino-terminal domain of the carp granulin-1 protein and its amino-terminally truncated 3-30 subfragment: implications for the conformational stability of the stack of two beta-hairpins

How to measure and predict the molar absorption coefficient of a protein

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

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706784

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10.1110/PS.073295308

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4

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18359860

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