C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
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Structural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelStructure, dynamics and implied gating mechanism of a human cyclic nucleotide-gated channelDouble electron-electron resonance reveals cAMP-induced conformational change in HCN channels.The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change.Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.Molecular mechanism underlying phosphatidylinositol 4,5-bisphosphate-induced inhibition of SpIH channels.cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.Structural changes during HCN channel gating defined by high affinity metal bridges.Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides.A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channelsDisease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells.Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactionsStructural basis of ion permeation gating in Slo2.1 K+ channels.Flavonoid regulation of HCN2 channels.New perspectives in cyclic nucleotide-mediated functions in the CNS: the emerging role of cyclic nucleotide-gated (CNG) channels.HCN Channels Modulators: The Need for Selectivity.HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b.The Arabidopsis AtPP2CA Protein Phosphatase Inhibits the GORK K+ Efflux Channel and Exerts a Dominant Suppressive Effect on Phosphomimetic-activating Mutations.Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance.CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel.Structural insights into the mechanisms of CNBD channel function.The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect.A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia.An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channelResonance assignment of the ligand-free cyclic nucleotide-binding domain from the murine ion channel HCN2HCN Channels: New Therapeutic Targets for Pain Treatment
P2860
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P2860
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@ast
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@en
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@nl
type
label
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@ast
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@en
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@nl
prefLabel
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@ast
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@en
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@nl
P2093
P2860
P356
P1476
C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels
@en
P2093
Kimberley B Craven
Nelson B Olivier
William N Zagotta
P2860
P304
P356
10.1074/JBC.M710463200
P407
P577
2008-05-23T00:00:00Z